目的 研究北葶苈子Lepidium apetalum的化学成分。方法 采用Diaion HP-20、Toyopearl HW-40、MCI Gel CHP-20、ODS、硅胶、半制备液相等柱色谱技术进行分离，经波谱分析鉴定化合物的结构。结果 从北葶苈子水提物中分离得到9个木脂素类化合物，分别鉴定为北葶新木脂素A（1）、北葶新木脂素B（2）、erythro-1-（4-O-β-D-glucopyranosyl-3-methoxyphenyl）-2-[4-（3-hydroxypropyl）-2，6-dimethoxyphenoxy]-1，3-propanediol（3）、（7R，7'E，8S）-4，9-dihydroxy-3，3'，5-trimethoxy-4'，7-epoxy-8，5'-neolign-7'-en-9'-oic acid（4）、spicatolignan B（5）、松脂醇-4'-O-β-D-吡喃葡萄糖苷（6）、异落叶松脂素（7）、aegineoside（8）、丁香脂素-4'-O-β-D-单葡糖苷（9）。结论 化合物1、2为新化合物，命名为北葶新木脂素A和B，化合物3～9为首次从该植物中分离得到。

Objective To study the chemical constituents from the seeds of Lepidium apetalum. Methods Compounds were isolated from the water extract from the seeds of L. apetalum by using Diaion HP-20, Toyopearl HW-40, MCI Gel CHP-20, ODS, Silica gel chromatography and semi-preparative-HPLC. Results Nine compounds were isolated and identified as lepidiumlignan A (1), lepidiumlignan B (2), erythro-1-(4-O-β-D-glucopyranosyl-3-methoxyphenyl)-2-[4-(3-hydroxypropyl)-2,6-dimethoxyphenoxy]-1,3-propanediol (3), (7R,7'E,8S)-4,9-dihydroxy-3,3',5-trimethoxy-4',7-epoxy-8,5'-neolign-7'-en-9'-oic acid (4), spicatolignan B (5), (-)-pinoresinol-4-O-β-D-glucopyranoside (6), (-)-isolariciresinol (7), aegineoside (8), and (+)-syringaresinol-O-β-D-glucopyra-noside (9). Conclusion Compounds 1 and 2 are new compounds, named as lepidiumlignan A and lepidiumlignan B. Compounds 3-9 are isolated from the plants for the first time.

科学技术部国家重点基础研究发展计划“973计划”项目（2013CB531802）：宣泻利水中药的药性研究；呼吸疾病诊疗与新药研发河南省协同创新中心（2013638）