目的 观察半夏泻心汤对糖尿病胃轻瘫（DGP）大鼠肠道菌群及炎症因子的影响。方法 采用高脂高糖喂养联合ip STZ的方法制备DGP大鼠模型，将成模大鼠随机分为模型组，二甲双胍（1.80 g/kg）组，半夏泻心汤高、中、低剂量（10.20、5.10、2.55 g/kg）组，另设对照组。各组均连续ig给药4周，检测各组大鼠空腹血糖、胃残留率、肠推进率、血清D-木糖水平、肠道菌群、血清内毒素、免疫球蛋白A（IgA）及肠组织炎症因子水平。结果 与对照组相比，DGP模型大鼠体质量、肠推进率、菌群（拟杆菌、双歧杆菌、肠球菌、乳酸杆菌）数量、IgA及IL-10水平显著降低（P<0.01），空腹血糖、胃残留率、血清D-木糖、肠杆菌、内毒素及TNF-α水平显著升高（P<0.01）；与模型组比较，半夏泻心汤高、中剂量组大鼠体质量、肠推进率、菌群（拟杆菌、双歧杆菌、肠球菌、乳酸杆菌）数量、IgA、IL-10水平明显升高（P<0.05、0.01），空腹血糖、胃残留率、血清D-木糖水平、肠杆菌数量、内毒素及TNF-α水平明显降低（P<0.05、0.01），半夏泻心汤低剂量组对空腹血糖、肠推进率、拟杆菌数量、IgA水平影响较小。结论 半夏泻心汤能够有效调节DGP模型大鼠各项指标，改善肠道菌群比例，减轻内毒素作用，抑制炎症因子，提高肠道屏障功能，其作用机制可能与调控肠杆菌及炎症因子有关。

Objective To observe the effects of the Banxia Xiexin Decoction (BXD) on the intestinal flora and inflammatory factors of diabetic gastroparesis (DGP) rats. Methods The high fat and sugar feeding combined with intraperitoneal injection of STZ were used for the preparation of DGP rats model, which were randomly divided into model group, the metformin (1.80 g/kg) group, the low (2.55 g/kg), medium (5.10 g/kg), and high (10.20 g/kg) dose group of BXD, and the blank group with 10 rats in each group. Four weeks of continuous ig administration of fasting blood glucose (FBG), gastric residual rate, intestinal propulsion rate, serum D-xylose level, intestinal flora, serum endotoxin, immunoglobulin A, and inflammatory factors were detected. Results Compared with the blank group, the body weight, intestinal propulsion rate, flora (bacteroides, bifidobacterium, enterococcus, and lactobacilli) amount, IgA, and IL-10 in DGP model were significantly reduced (P < 0.01); FBG, gastric residual rate, serum D-xylose, enterobacter number, endotoxin, and TNF-α were significantly increased (P < 0.01); Compared with model group, high dose BD group of body weight, intestinal propulsion rate, flora (bacteroides, bifidobacterium, enterococcus, and lactobacilli) amount, IgA, and IL-10 level in the low, medium, and high dose group of Banxia Xiexin decoction were increased significantly (P < 0.05, 0.01), FBG, gastric residual rate, serum D-xylose, enterobacter number, endotoxin and TNF-α were significantly decreased (P < 0.05, 0.01). The FBG, intestinal propulsion rate, bacteroides number, and IgA level in the low-dose group were less affected. Conclusion BXD can effectively adjust the various indexes of DGP model rats, including improving the intestinal flora proportion, reducing endotoxin, inhibiting inflammation factors, and improving the intestinal barrier function, and the potential mechanism may be related to regulation of intestinal bacteria and inflammation factors.

国家自然科学基金资助项目（81774279）；国家中医药管理局资助项目（JDZX2015215）