目的 研究白藜芦醇（RES）原料药、聚乙二醇固体分散体（RES-PEG）在大鼠体内的药动学过程和药动学参数。方法 建立大鼠血浆中RES的HPLC-UV检测方法。考察大鼠ig给予RES原料药和RES-PEG以及尾iv RES后血药浓度变化。采用DAS3.0软件计算药动学参数。结果 RES质量浓度在10～2.5×10⁴ ng/mL内线性关系良好（r=0.999 3）；定量下限为10 ng/mL；日内和日间精密度RSD小于5.1%；准确度在-1.1%～0.7%；提取回收率在97.8%～104.1%。大鼠ig RES原料药和RES-PEG以及尾iv RES后，RES在大鼠体内消除半衰期（t_1/2）分别为（2.6±2.0）、（2.3±0.8）、（6.3±1.1）h，血药浓度曲线下面积（AUC_0～12）分别为（514.7±117.5）、（1 084.6±836.9）、（2 697.3±289.8）ng·h/mL；ig RES原料药和RES-PEG的达峰浓度（C_max）分别为（473.3±200.8）、（814.1±246.6）ng/mL。RES-PEG与原料药对比，其相对生物利用度约为200%；RES原料药的绝对生物利用度约为5%。结论 RES口服生物利用度低，RES原料药制备成固体分散体后相对生物利用度显著提高。

Objective To study the pharmacokinetics and pharmacokinetic parameter of resveratrol (RES) crude drug and solid dispersion (RES-PEG) in rats. Methods HPLC-UV was established for detecting plasma concentrations of RES and investigating its pharmacokinetics in rats with ig and iv administration. The software of DAS3.0 was used to process the pharmacokinetic parameters. Results The linear calibration curve was obtained in the range of (10-2.5×10⁴) ng/mL for RES, and the lower limit of quantitation was 10 ng/mL. Intra-and inter-day precision for all samples were less than 5.1%, and the accuracy of three different concentrations was in the range from -1.1% to 0.7%. The extraction recovery of RES from rat plasma was from 97.8% to 104.1%. The main pharmacokinetics parameters of RES crude drug and RES-PEG after ig administration, and RES after iv administration were shown as follows:t_1/2, (2.6 ±2.0), (2.3 ±0.8), and (6.3 ±1.1) h; AUC_0-12, (514.7 ±117.5), (1 084.6 ±836.9), and (2 697.3 ±289.8) ng·mL/h, respectively; the C_maxofRES crude drug and RES-PEG after ig administration were (473.3 ±200.8) and (814.1 ±246.6) ng/mL, respectively. Compared to crude drug, the relative bioavailability of of RES-PEG was about 200%; And the absolute bioavailability of RES crude drug was 5%. Conclusion The oral bioavailability of RES was low. The relative bioavailability of RES crude drug was significantly improved after being prepared into solid dispersion.