[关键词]
[摘要]
心房纤颤(atrial fibrillation,AF)为临床中最常见的心律失常之一,目前化学药对AF的治疗方法较少且副作用明显,中医药与化学药的联用有望提高疗效并减少副作用。对中药治疗AF的研究进展进行综述,并根据文献检索结果,对中药治疗AF的常用药材人参中人参皂苷的入血成分进行生物分子网络分析,探讨其治疗AF的可能作用机制。通过靶点检索、网络构建及GO生物进程的分析,推测人参皂苷的入血成分治疗AF的作用机制可能与调控细胞凋亡、细胞膜钾离子流动等相关。
[Key word]
[Abstract]
Atrial fibrillation (AF) is the most common type of arrhythmia in clinic. At present, the therapies of AF by western medicine are fewer with obvious side effects. It is expected to improve the curative effect and reduce side effects by the combination of traditional Chinese medicine (TCM) and western medicine. The research progresses of Chinese materia medica (CMM) treatment for AF were summarized, and the biological molecular network was carried out for the analysis of blood components of ginsenoside from the key CMM Panax ginseng in AF treatment. The blood components of ginsenoside in network analysis including targets searching, network construction, and GO biological processes analysis were selected to explore the possible mechanism in treating AF. It indicated that the possible mechanism might be related to apoptosis regulation, cell membrane potassium ion flow, and so on.
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