气分热是卫气营血辨证中气分证的一个证候群，白虎汤是清气分热的经典名方，若阳明气分热兼气津两伤则用白虎汤加人参。为探讨人参促白虎汤解热作用的机制，应用网络药理学方法，在总结人参对免疫系统的作用及发热与免疫系统关系的基础上，首先通过TCMSP数据库在限定条件下筛选得到人参22个活性成分及其对应的靶标，采用HPO数据库检索发热相关疾病靶标；然后通过STRING数据库将人参活性成分对应靶标和发热相关疾病靶标构建"人参-靶标-发热"网络，应用Cytoscape软件将上述网络可视化后，根据相关特征参数得到18个关键节点；再由GATHER数据库平台对关键节点进行基因功能富集分析。经上述网络构建及拓朴测算发现人参可能通过调控MyD88依赖型或MyD88非依赖型Toll样受体信号通路激活天然免疫系统，达到促进白虎汤解热作用的效果。

Qi-fen fever is a syndrome of Qi-fen syndrome in defensive qi nutrient blood syndrome differentiation. Baihu Decoction is a classic prescription of cooling Qi-fen, but when yang brightness heat at qi aspect is too exuberance to hurt human healthy qi and body fluid, Baihu with Ginseng Decoction will be used for treatment. In order to explore the mechanism of antipyretic effects of Baihu with Ginseng Decoction, this paper applied the network pharmacology method on the basis of summarizing the effects of ginseng on the natural immune system and the relationship between fever and the natural immune system. Firstly, 22 chemically active components of ginseng and their corresponding targets were screened by TCMSP database under limited conditions, and HPO database was used to search for fever-related disease targets. Secondly, the "ginseng-target-fever" network was constructed by STRING database corresponding to ginseng chemical active ingredients target and fever-related disease targets, and Cytoscape software was used to visualize the above network and obtained 18 key nodes according to the relevant characteristic parameters. Finally, The GATHER database platform was applied for the enrichment analysis of the gene function of key nodes. According to the network construction and topological calculation, it suggests that ginseng could activate the natural immune system by regulating MyD88-dependent or MyD88-independent Toll-like receptor signaling pathway to promote the antipyretic effects of Baihu Decoction.

国家自然科学基金资助项目（81503492，81473617）；湖南省自然科学基金资助项目（2015JJ6079）；湖南省教育厅开放基金平台项目（15K091）；湖南省教育厅教改课题（湘教通[2016]400-321）；湖南中医药大学教改课题（2014JG010）