目的 研究紫堇Corydalis edulis全草的化学成分。方法 采用硅胶、Sephadex LH-20、ODS柱色谱和半制备HPLC等色谱方法分离纯化，结合其理化性质和MS、NMR等波谱学数据鉴定化合物的结构。结果 从紫堇乙醇提取物的正丁醇萃取部位分离鉴定了15个化合物，分别鉴定为6，7-亚甲二氧基二氢异香豆素（1）、oxohydrastinine（2）、6，7-dimethoyisoquinolin-1（2H）-one（3）、6，7-methylenedioxy-1（2H）-isoquinolinone（4）、（+）-丁香树脂素（5）、梣皮树脂醇（6）、红景天苷（7）、1-（2-羟基苄基）-β-D-吡喃葡萄糖苷（8）、淫羊藿次苷D₂（9）、水杨苷（10）、淫羊藿次苷F₂（11）、淫羊藿次苷B₂（12）、烟酰胺（13）、邻苯二酚（14）和5-羟基-2-羟甲基吡啶（15）。结论 化合物1为新天然产物，化合物3、5~12、14和15为首次从紫堇属植物中分离得到，化合物2、4和13为首次从紫堇中分离得到。

Objective To investigate the chemical constituents from the herbs of Corydalis edulis. Methods The compounds were isolated and purified by various column chromatographies, and their structures were identified by physiochemical properties and spectroscopic data. Results Fifteen compounds were isolated from the n-BuOH layer of EtOH extract of the herbs of C. edulis. and identified as 6,7-methylenedioxydihydroisocoumarin (1), oxohydrastinine (2), 6,7-dimethoyisoquinolin-1 (2H)-one (3), 6,7-methylenedioxy-1 (2H)-isoquinolinone (4), (+)-syringaresinol (5), (+)-medioresinol (6), salidroside (7), isosalicin (8), icariside D₂ (9), salicin (10), icariside F₂ (11), icariside B₂ (12), nicotinamide (13), pyrocatechol (14), and 5-hydroxyl-2-hydroxymethylpyridine (15), respectively. Conclusion Compound 1 is a new natural product. Compounds 3, 5-12, 14, and 15 were isolated from Corydalis species for the first time. Compounds 2, 4, and 13 were firstly obtained from C. edulis.

教育部新世纪优秀人才支持计划资助项目（NCET-13-0693）；北京中医药大学自主课题（2017-JYB-XS-069）