菊科苍术属白术Atractylodes macrocephala的干燥根茎为白术的药用部位，是常用的传统中药，具有健脾、美容等功效。挥发油是白术的主要药用成分，其中主要含有倍半萜类化合物，具有明显的抗肿瘤作用。近年来，白术的市场需求量逐渐增加，然而其质量却参差不齐。对白术次级代谢产物挥发油中倍半萜的生物合成和转化途径进行综述，并从遗传和生态角度总结了影响白术挥发油积累的主要因素，以期为研究白术倍半萜的合成和转化途径提供参考，为提高白术挥发油的产量和品质提供帮助。

Atractylodes macrocephala, belonging to Compositae family, whose dry rhizome as its medicinal parts, is a famous traditional Chinese medicine, with the function of tonifying spleen, aesthetic improvements and so on. Its main medicinal ingredient is volatile oil, which has obviously effect of antitumor. Recently, the market demand of this herb gradually increased, while its quality has not been guaranteed. This paper concluded the process of biosynthesis and transformation of sesquiterpenoids, an important secondary metabolite in violate oil; And firstly reviewed the factors affecting the accumulation of volatile oil in A. macrocephala in the aspects of inheritance and ecology. It is expected to provide a reference for the further study of the biosynthesis and biotransformation of sesquiterpenoids in A. macrocephala and help to improve the yield and quality of the volatile oil.

南京市产学研合作项目（201306019）