[关键词]
[摘要]
中药谱效学是针对中药药效物质基础及其作用机制研究的一种有效方法,即首先采用不同现代分析手段获取中药的化学成分信息,并选取适当的动物模型进行药理活性评价,再根据统计学方法的结果将上述2种实验数据加以分析整合,从而找出发挥作用的关键药效物质。目前中药谱效学的应用十分广泛。主要就谱效学在中药的质量评价研究、中药的提取纯化工艺研究以及中药炮制前后活性物质变化研究等方面的应用进行总结,为中药的进一步相关研究提供参考。
[Key word]
[Abstract]
The study of spectrum-effect relationship is one effective method according to the pharmacodynamic material basis and mechanism of action of Chinese materia medica (CMM). The first step is to adopt different modern analysis methods to obtain the compound information of CMM, secondly choose proper animal model to evaluate the pharmacological activity, and then combine two kinds of information mentioned above to find out the main effective substance based on the results of statistical methods. Nowadays, the study of spectrum-effect relationship is widely used in many different aspects. In this article, three different applications of spectrum-effect relationship were mainly summarized, including the study of the quality assessment of CMM, the study of extraction and purification method of CMM and the study of processed CMM, in order to provide reference for the further study of CMM.
[中图分类号]
[基金项目]
国家自然科学基金项目(21275169);重庆市基础与前沿研究计划项目(cstc2015jcyjA10044)