目的 优化三七跌打软膏剂基质处方并对其体外透皮特性进行研究。方法 在预试验的基础上，采用Box-Behnken法，以外观性状、高温实验、低温实验、离心实验评分为指标优化三七跌打软膏基质最优处方，采用改良Franz扩散池法，以血竭素、人参皂苷Rg₁、川续断皂苷VI、人参皂苷Rb₁为评价指标，考察不同薄荷醇促渗剂对软膏体外透皮渗透量的影响。结果 三七跌打软膏最优处方为十二烷基硫酸钠-硬脂醇-凡士林（1.61：26.72：27.10）；不同浓度的促渗剂对血竭素、人参皂苷Rg₁、川续断皂苷VI、人参皂苷Rb₁促渗效果均较好，3%的促渗剂对指标成分促渗效果及制剂稳定性较好，体外透皮速率依次为3.971、6.368、0.415、2.780 μg/（cm²∙h）。结论 优化的三七跌打软膏剂膏体均匀，稠度适宜，易涂布，具有较好的释药性和透皮性，透皮行为符合零级动力学过程。

Objective To prepare Sanqi Traumatic Ointment (STO) and study its transdermal permeation properties in vitro. Methods In this paper, the appearance description, high-temperature test, low-temperature test and centrifugal test were taken as indexes. Based on the result of a single factor experiment, the formula for the STO was optimized by Box-Behnken test. Franz diffusing cells method was chosen to investigate the tansdermal infiltration capacity of ointment with different mentha camphor penetration enhancers' in vitro, taking dracorhodin, ginsenoside Rg₁, asperosaponi VI, and ginsenoside Rb₁ as index components. Results The optimal ratio of the prescription was as follows:lauryl sodium sulfate-stearyl alcohol-vaseline (1.61:26.72:27.10). The promoting effect of different concentration of penetration enhancers on dracorhodin, ginsenoside Rg₁, ginsenoside VI, and asperosaponin Rb₁ penetration were better; The promoting effect of 3% concentration for index component was better, and this preparation had good stability; The transdermal rates of dracorhodin, ginsenoside Rg₁, asperosaponi VI, and ginsenoside Rb₁ were 3.971, 6.368, 0.415, and 2.780 μg/(cm²∙h). Conclusion STO had a good release and transdermal properties, and transdermal actions were consistent with zero-order kinetics.

重庆市科委应用开发重大项目（cstc2014yykfC10006）