目的 考察血竭三七接骨膏（XSJP）中不同粉体粒径和体外溶出度之间的相关性。方法 采用激光粒度仪测定3种不同XSJP粉体（超微粉、极细粉、细粉）的粒径分布；采用桨法，以羟基红花黄色素A、三七皂苷R₁、人参皂苷Rg₁、川续断皂苷VI、人参皂苷Rb₁、血竭素6种成分为评价指标考察上述不同粉体溶出度，采用SPSS 17.0软件对不同粒径粉体与所对应的溶出度进行相关性分析。结果 3种粉体的粒径与指标成分溶出度具有相关性，其中羟基红花黄色素A、三七皂苷R₁、人参皂苷Rg₁、川续断皂苷VI、人参皂苷Rb₁ 5种成分累积释放率与粒径呈负相关，超微粉较细粉累积溶出率分别提高6.8%、16.6%、6.6%、6.7%、5.4%，血竭素无相关性。结论 含有细胞结构的纤维类药材不同粉体粒径与其溶出度存在相关性。

Objective To investigate the relationship between powder particle size and dissolution of Xuejie Sanqi Jiegu Paste (XSJP) in vitro. Methods The particle size of three kinds of XSJP was measured by laser particle size instrument. The hydroxysafflor yellow A, asperosaponin VI, ginsenoside Rg₁, ginsenoside Rb₁, notoginsenoside R₁, dracorhodin were taken as indexes, and the feature of dissolution for the above three kinds of XSJP was examined by grouting method. The correlation between the powders in different particle sizes and their corresponding dissolution was analyzed by software SPSS 17.0. Results The particle size of the three kinds of powders was correlated with the dissolution of index components. The powders in different particle sizes were negatively correlated with the relative cumulative dissolution of hydroxysafflor yellow A, asperosaponin VI, ginsenoside Rg₁, ginsenoside Rb₁ and notoginsenoside R₁. The cumulative dissolution of superfine powder was respectively increased by 6.8%, 16.6%, 6.6%, 6.7%, and 5.4%, while the dracorhodin had no direct correlation. Conclusion There is a correlation between the particle size and dissolution of Chinese medicine with fibre which contains cellular structure.

重庆市科委应用开发重大项目（cstc2014yykfC10006）