[关键词]
[摘要]
癌细胞的上皮-间质转化(EMT)效应、细胞迁移以及侵袭能力在癌症转移过程中起到重要作用。白藜芦醇是在葡萄、浆果以及花生皮中发现的一种天然多酚。多项研究表明白藜芦醇及其代谢产物与类似物具有多种靶向抗癌作用。综述白藜芦醇及其代谢产物或类似物通过影响与EMT、癌症迁移和向不同器官侵袭有关的多种信号传导途径来抑制癌症转移的研究进展,以期为白藜芦醇在癌症治疗中的应用提供参考。
[Key word]
[Abstract]
The epithelial-mesenchymal transition (EMT) effect, cell migration, and invasion ability of cancer cells play important roles in the process of cancer metastasis. Resveratrol is a natural polyphenol found in grapes, berries, and peanut skins. Many experimental studies have shown that resveratrol and its metabolites and analogs have multiple targeting anti-cancer effects. The aim of this study is to provide resveratrol and its metabolites and analogues to inhibit the potential for cancer metastasis by influencing many signaling pathways associated with EMT, cancer migration and different organ invasion. We found that resveratrol's metabolites and analogues can inhibit the EMT process by affecting the role of multiple signaling pathways, inhibiting the metastasis and erosion of cancer through the literature review.
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