目的 优选艳山姜Alpiniae zerumbet挥发油自乳化释药系统（EOFAZ-SEDDS）的处方，并对其药剂学性质进行评价。方法 通过伪三元相图的绘制，以乳化区域面积为指标，筛选处方中乳化剂、助乳化剂、乳化剂与助乳化剂比例（K_m），确定最佳处方，并对EOFAZ-SEDDS的外观、粒径、自乳化效率以及稳定性进行评价。结果 所得艳山姜挥发油自乳化传递系统的处方为艳山姜挥发油（60%）、Kolliphor HS 15（20%）、无水乙醇（20%）。所得EOFAZ-SEDDS外观为淡黄色澄明液体，加水稀释后可形成乳白色并带淡蓝色乳光的乳液，于透射电子显微镜（TEM）下观察呈球形，分布均匀，粒径为（171.67±7.64）nm，Zeta电位为（-11.51±1.22）mV。EOFAZ-SEDDS在盐酸（0.1 mol/L）中自乳化时间最短。随着介质体积的增加，自乳化时间延长。EOFAZ-SEDDS自乳化后24 h内均未见有沉淀产生和分层现象，且离心30 min仍未发生分层。结论 研究考察所得最佳处方制备的EOFAZ-SEDDS粒径适宜，稳定性良好。

Objective To optimize the formulation of essential oil of Alpiniae zerumbet self-emulsifying drug delivery system (EOFAZ-SEDDS) and evaluate its pharmacological properties. Methods The emulsifiers, co-emulsifiers and ratio of emulsifier to co-emulsifier (K_m) were selected through the pseudo-ternary phase diagram method, using emulsified area as selection index, and determine the optimal prescription. The appearance, particle diameter, self-emulsification efficiency, and stability were evaluated. Results The optimal SEDDS was composed of volatile oil (60%), Kolliphor HS 15 (20%), and anhydrous ethanol (20%). The appearance of EOFAZ-SEDDS was translucent diluted-yellow solution. EOFAZ-SEDDS diluted with water to form milky and pale blue emulsion with a particle size of (171.67 ±7.64) nm and Zeta potential of (-11.51 ±1.22) mV. The emulsion was observed to be spherical by transmission electron microscopy and distributed evenly. The self-emulsifying time of EOFAZ-SEDDS in hydrochloric acid (0.1 mol/L) was short. With the increase of the volume of medium, the self-emulsifying time was prolonged. The precipitation and delamination of EOFAZ-SEDDS were not observed within 24 h after self-emulsifying, and no stratification was observed after 30 min centrifugation. Conclusion The EOFAZ-SEDDS prepared by optimum formulationthe of this study has a good particle size and good stability.

国家自然科学基金资助项目（81760725，81360650）；筑科合同[20151001]药07号；贵州省留学人员科技活动项目经费（黔人项目资助合同[2013]02号）；贵州省科技合作项目（黔科合LH字[2016]7368）；贵州省高等教育科技创新团队（黔教合人才团队字[2014]31）；贵州省科技创新创新团队（黔科合人才团队[2015]4025号）；贵州省高层次创新型人才百层次人才（贵州科技厅黔科合人才[2015]4029号）；贵州省教育厅拔尖人才计划（黔教合KY2016[073]）