目的 基于中医整体观、动态观，平行比较艾片、天然冰片、合成冰片、苏合香、安息香5种开窍药调节脂多糖（LPS）致发热模型大鼠生理指标的作用节点及强度。方法 采用Data Science International（DSI）植入式生理信号遥测技术，动态观测开窍药对模型大鼠体温（T）、心率（HR）、血压（SBP、DBP）、活动度（A）等生理参数的影响，用SPSS 17.0、SAS 9.2、OriginPro 8.5处理数据及作图。结果 3种冰片（艾片、天然冰片、合成冰片）对模型大鼠的T、HR有抑制作用，艾片最优；苏合香对模型大鼠HR、SBP、DBP、A等总体呈现先兴奋后抑制趋势；安息香对各项指标无显著影响。主成分分析结果显示天然冰片、苏合香对模型大鼠作用有一致倾向性；合成冰片能同时对A、SBP、DBP产生较大影响。聚类分析和对应分析均表明3种冰片的作用特点可归为一类；苏合香、安息香具有各自作用规律。结论 3种冰片对各生理指标有抑制作用；苏合香整体呈现出先兴奋后抑制趋势，可能与其性温的时间窗有关；安息香对发热模型无显著影响，可能与其平性相关；今后可从开窍药对该模型大鼠作用机制展开研究。

Objective To compare l-Borneolum, Borneolum, Borneolum Syntheticum, Styrax, and Benzoinum for regulating the physiological index of node and strength in a rat model of lipopolysaccharide (LPS)-induced fever in parallel based on the overall concept of tradition Chinese medicine (TCM) and the idea of dynamic view. Methods The influence of resuscitation inducing aromatic herbs on rats with normal activities of body temperature (T), heart rate (HR), blood pressure (SBP and DBP), activity (A), and other physiological parameters were dynamically monitored by DSI implantable physiological signal telemetry technology. The data were processed and mapped by SPSS 17.0, SAS 9.2, and OriginPro 8.5. Results Three kinds of borneol showed inhibitory effect on T and HR of model rats, and l-Borneolum had the optimal inhibitory effect; Styrax showed the excitation-inhibition trend on HR, SBP, DBP, and A of model rats; Benzoinum had no obvious effect on each index. The results of principal component analysis showed that Borneolum and Styrax had the same orientation in model rats; Borneolum Syntheticum could simultaneously affect A, SBP, and DBP. Cluster analysis and correspondence analysis showed that characteristics of three kinds of borneol can be classified as the same kind; Benzoinum and Styrax had their own affect rules. Conclusion The three kinds of drugs have inhibitory effect on each physiological index; Styrax has the excitation-inhibition trend, which is related to the previous understanding of its time-window;Benzoinum has no effect on model rats, which is related to its evenness. The future research can be expanded on the mechanism of resuscitation drugs on rats with LPS-induced fever.

国家自然科学基金项目（81473371）；国家基础科学人才培养基金“成都中医药大学中药基础基地科研训练及科研能力提高项目”（J1310034）