目的 研究喷雾干燥法制备莪术油微囊的最佳处方及最佳工艺。方法 以微囊粒径、微囊形态、包埋率为考察指标，采用单因素实验对囊材配比、芯材与囊材比、干物质用量、附加剂PEG6000用量、乳化速度、乳化时间、进风温度、进料功率进行了研究，筛选出莪术油微囊的最佳处方及最佳工艺。结果 喷雾干燥法制备莪术油微囊的最佳处方为阿拉伯胶-明胶（1.0∶1.0），芯材-囊材（0.30∶1.0），附加剂PEG6000用量2%，干物质用量20%；最佳工艺为乳化速度10 600 r/min，乳化时间9 min，进风温度160 ℃，进料功率6%。根据最佳实验条件制得的微囊较圆整，表面致密，粒径分布均匀，多数集中在1.0～2.5 μm，且呈较好的正态分布，平均粒径1.913 μm，包埋率可达75.4%。结论 本实验采用的方法可增加莪术油的稳定性，掩盖其不良气味，且药物利用率较高，重复性好。

Objective To establish the optimal prescription and technique for preparing zedoary turmeric oil (ZTO) microcapsule. Methods Using the diameter of microcapsule, microcapsule form, and embedding rate as indexes, the ratio of capsule materials, ratio of core material and capsule material, content of dry matter, content of additive, speed of emulsifying, time of emulsifying, temperature of wind and the power of feed were studied. Results The optimal conditions for preparation of spray drying of ZTO microcapsule were as follows: gum Arabic-gelatin (1.0:1.0), core material-capsule material (0.30:1.0), PEG6000 content of 2%, dry matter content of 20%; The optimal technique was as follows: The emulsion speed was 10 600 r/min, emulsifying time was 9 min, temperature of inlet air was 160 ℃, and feed power was 6%. According to the optimum experimental conditions, the microcapsule was round relatively, the surface density was well, the particle size of microcapsule appeared uniform distribution, most concentrates in 1.0—2.5 μm, and showed good normal distribution, the average particle size was 1.913 μm, the embedding rate could reach 75.4%. Conclusion This experiment can increase the stability of ZTO, cover up its bad smell, and raise the utilization ratio of drugs, the repeatability is also good.

浙江省中医药管理局项目（2011ZA075）