毛酸浆Physalis pubescens作为药食两用植物，已有1 200多年的悠久历史。目前研究发现，毛酸浆主要含黄酮类、甾体类、苯丙素类、生物碱类、脂肪酸类等多种化学成分，具有抗肿瘤、抗菌、抗氧化、利尿、免疫抑制等多种药理活性。查阅近30年国内外文献，针对毛酸浆的化学成分、药理作用等方面进行综述，并对毛酸浆的开发利用前景进行展望，为进一步合理开发和综合利用毛酸浆的药用资源提供参考。

Physalis pubescens is used as both food and medicine over 1 200 years. From the phytochemical view, the second metabolites such as flavonoids, sterols, phenylpropanoids, alkaloids, fatty acid and so on have been reported from this species. And this plant shows the activities of antitumor, antimicrobial, anti-oxidant, diuresis, immunosuppressive and so on in the recent studies. This paper reviews the researches on the chemical constituents and pharmacological activities of this plant in recent 30 years, by which the prospect of development and utilization of P. pubescens could be prospected. It provides the reference for the further rational development and comprehensive utilization of the resources of P. pubescens.