目的 研究洋金花Daturae Flos根中苯丙素类化学成分。方法 采用硅胶、ODS及HPLC等色谱方法分离化合物，利用NMR、MS波谱学方法鉴定其结构。结果 从洋金花根70%乙醇回流提取物的正丁醇部位分离得到19个化合物，分别鉴定为淫羊藿苷 E5（1）、alangisesquin A（2）、glycopentoside F（3）、conicaoside（4）、（7S，8R）-dehydrodiconiferyl alcohol 9'-O-β-glucopyranoside（5）、落叶松脂醇-4'-O-β-D-葡萄糖苷（6）、7R，8R-threo-4，7，9-trihydr-oxy-3，3'-dimethoxy-8-O-4'-neolignan-9'-O-β-D-glucopyranoside（7）、vitrifol A（8）、leptolepisol D（9）、苏式-2，3-二-（4-羟基-3-甲氧基苯）-3-甲氧基丙醇（10）、hyuganoside IIIb（11）、officinalioside（12）、落叶松脂醇-9-O-β-D-葡萄糖苷（13）、stroside A（14）、erythro-buddlenol B（15）、sargentodoside D（16）、（+）-（7S，8S）-4-hydroxy-3，3'，5'-trimethoxy-8'，9'-dinor-8，4'-oxy-neolignan-7，9-diol-7'-oic acid（17）、5'-甲氧基落叶松脂醇（18）、dehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside（19）。结论 化合物2～19为首次从茄科植物中分离得到，化合物1为首次从曼陀罗属植物中分离得到。

Objective To study the phenylpropanoids from the roots of Datura metel. Methods The separations and purifications were taken by silica gel and ODS chromatogram columns as well as preparative HPLC, and the structural identification based on physicochemical property, ¹H-NMR and ¹³C-NMR as well as HR-MS data. Results Nineteen compounds obtained from the butanol fraction of the 70% ethanol extract of D. metel roots, which were identified as icariside E5 (1), alangisesquin A (2), Glycopentoside F (3), conicaoside (4), (7S,8R) dehydrodiconiferyl alcohol 9'-O-β-glucopyranoside (5), iariciresinol-4'-O-β-D-glucopyranoside (6), 7R,8R-threo-4,7,9-trihy-droxy-3,3'-dimethoxy-8-O-4'-neolignan-9'-O-β-D-glucopyranoside (7), vitrifol A (8), leptolepisol D (9), thero-2,3-bis-(4-hydroxy-3-methoxypheyl)-3-methoxy-propanol (10), hyuganoside IIIb (11), officinalioside (12), iariciresinol-9-O-β-D-glucopyranoside (13), stroside A (14), erythro-buddlenol B (15), sargentodoside D (16), (+)-(7S,8S)-4-hydroxy-3,3',5'-trimethoxy-8',9'-dinor-8,4'-oxyneolignan-7,9-diol-7'-oic acid (17), 5'-methoxy lariciresinol (18), and dehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside (19). Conclusion Compounds 2—19 are isolated from Solanaceae family for the first time and compound 1 is firstly isolated from genus Datura L.

黑龙江省普通高等学校长江学者后备支持计划项目（2013CJHB006）