过氧化物酶体增长因子活化受体（peroxisome proliferators-activated receptors，PPARs）是核受体超家族中的配体激活转录因子，有3种亚型（α、β、γ），控制着细胞内多种代谢过程，代谢综合征等疾病的发生均可能与其异常调控有关，成为医学界和生物界热门研究的靶点。而目前市场上应用的合成类的PPARs激动剂伴随着一系列的副作用，因此，从天然产物中寻找安全、有效的PPARs激动剂成为当前研究的热点。

Peroxisome proliferators-activated receptors (PPARs) are ligand activated transcription factors belonging to the nuclear receptor superfamily, including three subtypes (α, β, and γ). PPARs are responsible for a variety of metabolic processes in the cell, and the occurrence of metabolic syndrome and other diseases may be related to the abnormal regulation, which has become a hot research target in the medical and biological fields. At present, the synthesis of PPARs agonists in the market is accompanied with a series of side effects, therefore, the search for safe and effective PPARs agonists from natural products has become the main trend of current research.

国家自然科学基金资助项目（81302664）；河北省教育厅重点课题（ZD2016093）；河北省中医药管理局课题（2016040）