目的 研究海南狗牙花Ervatamia hainanensis枝叶的化学成分。方法 采用硅胶、ODS、Sephadex LH-20及制备型HPLC等柱色谱方法进行分离纯化，根据理化性质及波谱学数据鉴定化合物结构。结果 从海南狗牙花枝叶的95%乙醇提取物中分离得到了4个木脂素类成分，分别鉴定为threo-7-O-ethylguaiacylglycerol-8-O-4'-（coniferyl alcohol） ether（1）、threo-guaiacylglycerol-8-O-4'-（coniferyl alcohol） ether（2）、erythro-guaiacylglycerol-8-O-4'-（coniferyl alcohol） ether（3）、去氢二松柏醇（4）。结论 化合物1为1个新的8-O-4'-木脂素类成分，命名为海南狗牙花脂素A（1）；化合物2~4为首次从狗牙花属植物中分离得到。

Objective To study the chemical constituents in the twigs and leaves of Ervatamia hainanensis. Methods The chemical constituents were isolated by silica gel, ODS, Sephadex LH-20 column chromatographies, and preparative HPLC. The structures were elucidated on the basis of physicochemical properties and spectral analysis. Results Four lignans were isolated and identified as threo-7-O-ethylguaiacylglycerol-8-O-4'-(coniferyl alcohol) ether (1), threo-guaiacylglycerol-8-O-4'-(coniferyl alcohol) ether (2), erythro-guaiacylglycerol-8-O-4'-(coniferyl alcohol) ether (3), and dehydrodiconiferyl alcohol (4). Conclusion Compound 1 is a new 8-O-4'-neolignan and named as hainanervaligan A (1), and compounds 2-4 are obtained from the plants of Ervatamia (A. DC.) Stapf for the first time.

广东省自然科学基金项目（2016A030310017）；广东省高等职业教育品牌专业建设项目（16061）