目的 研究泰山产天目琼花Viburnum sargentii枝叶的化学成分。方法 利用硅胶柱色谱、凝胶Sephadex LH-20柱色谱，中压反相硅胶柱色谱以及高效液相色谱等各种现代色谱方法进行分离纯化；通过ESI-MS、1D-NMR、2D-NMR等现代波谱技术，并与文献数据对照鉴定化合物的结构。结果 从天目琼花枝叶95%乙醇提取物中分离鉴定了13个化合物，包括7个三萜类化合物：α-香树脂醇（1）、熊果醇（2）、3α-乌苏酸（3）、11，12-去氢熊果酸内酯（4）、3-乙酰基齐墩果醛（5）、齐墩果酸（6）、白桦脂酸（7）；5个木脂素类化合物：木兰脂素（8）、（+）-桉脂素（9）、（-）-表桉叶明（10）、vibsanol（11）、3，4'-dimethoxylvibsanol（12）；1个苯丙素类化合物：α-细辛醚（13）。结论 化合物12是1个新的天然产物，化合物1~11和13均为首次从天目琼花植物中分离得到。

Objective To study the chemical constituents from the branches and leaves of Viburnum sargentii collected at Mountain Tai. Methods The chemical constituents were isolated and purified by chromatographic methods, including silica gel, ODS, Sephadex LH-20 columns, and RP HPLC. The structures of the isolated compounds were identified by ESI-MS, 1D-NMR, and 2D-NMR data analyses, and compared with the literature data. Results Thirteen compounds were obtained from the 95% ethanol extract of branches and the leaves of V. sargentii, and determined as α-amyrin (1), uvaol (2), 3α-ursolic acid (3), 11,12-dehydroursolic acid lactone (4), 3-O-acetyloleanolic aldehyde (5), oleanolic acid (6), betulinic acid (7), magnolin (8), (+)-eudesmin (9), (-)-epieudesmin (10), vibsanol (11), 3,4'-dimethoxylvibsanol (12), and α-asarone (13), respectively. Conclusion Compound 12 (3,4'-dimethoxylvibsanol) is a new natural product, and compounds 1-11 and 13 are isolated from V. sargentii for the first time.

山东省高等学校科技计划项目（J13LM02）；泰安市科技引导计划项目（2015NS2150，2015NS2135）；山东省科技发展计划项目（2015GSF119008）