目的 对海蒿子Sargassum pallidum全草进行含氮有机化学成分研究。方法 采用D101大孔吸附树脂柱色谱、正相硅胶柱色谱、凝胶柱色谱、ODS柱色谱、高效液相色谱等方法对含氮有机化学成分进行分离纯化，并根据其理化性质和核磁共振谱、质谱等光谱学技术鉴定所分离化合物的结构。结果 从海蒿子全草70%乙醇提取部位分离得到了10个化合物，分别鉴定为（-）-伞形香青酰胺（1）、（-）-栝楼酯碱（2）、（-）-金色酰胺醇酯（3）、核黄素（4）、β-腺苷（5）、2'-Ο-甲氧基尿嘧啶核苷（6）、环（L-丙氨酸-L-脯氨酸）（7）、胸腺嘧啶核苷（8）、1-（β-D-ribofuranosyl）-1H-1，2，4-triazone（9）、2，3-二氢-4（1H）-喹诺酮（10）。结论 化合物1、2、4~7、9为首次从马尾藻属植物中分离得到。

Objective To study the nitrogenous compounds of Sargassum pallidum. Methods The compounds were separated and purified by D101 macroporous adsorptive resins, silica gel chromatography, Sephadex LH-20 chromatography, ODS column chromatography, and HPLC methods. Their structures were identified on the basis of physical and chemical properties and spectroscopic data (¹H-NMR, ¹³C-NMR, and MS). Results Ten compounds were isolated from S.pallidum and identified as (-)-anabellamide (1), (-)-trichosanatine (2), (-)-aurantiamide acetate (3), riboflavin (4), β-adenosine (5), 2'-Ο-methoxyluridine (6), cyclo (L-Ala-L-Pro) (7), thymidine (8), 1-(β-D-ribofuranosyl)-1H-1,2,4-triazone (9), and 2,3-dihydro-4 (1H)-quinolone (10). Conclusion Compounds 1, 2, 4-7, and 9 are isolated from the genus Sargassum (Turn.) C. Ag. for the first time.

国家自然科学基金重点项目（81430095）