目的 对川木香Vladimiria soulie根中倍半萜类成分进行研究。方法 采用正相硅胶柱色谱、Sephadex LH-20柱色谱、中压色谱、薄层制备、反相高效液相色谱等方法进行分离纯化，并根据其理化性质和波谱数据等鉴定化合物的结构。结果 从川木香根中共分离得到了9个化合物，分别鉴定为15-乙酰氧基-11αH-吉玛烷-1（10）E，4E-二烯-12，6α-内酯（1）、15-乙酰氧基-11βH-吉玛烷-1（10）E，4E-二烯-12，6α-内酯（2）、12-羟基-5α（H），7α（H）-桉叶烷-4（14），11（13）-二烯-9-酮（3）、oplodiol（4）、dihydroestafiatone（5）、10-oxo-dihydroxy-11β，13-dihydrodehydrocostuslactone（6）、（11S）-13-羟基-愈创木烷-4（15），10（14）-二烯-12，6α-内酯（7）、9-氧橙花叔酮（8）、vernopolyanthone（9）。结论 化合物1和3为新化合物，分别命名为川木香烃二酯和川木香二烯酮；化合物4~9首次从川木香根中分离得到。

Objective To study the sesquiterpenes from the roots of Vladimiria souliei. Methods The compounds were isolated by silica gel, Sephadex LH-20, medium pressure chromatographic column, preparative-TLC, and preparative-HPLC. And their structures were identified by means of chemical methods and spectroscopic analyses. Results Nine compounds were isolated from V.souliei, and named as 15-acetoxy-11αH-germacra-1(10)E,4E-diene-12,6α-olide (1), 15-acetoxy-11βH-germacra-1(10)E,4E-diene-12,6α-olide (2), 12-hydroxy-5α(H),7α(H)-eudesm-4(14),11(13)-diene-9-one (3), oplodiol (4), dihydroestafiatone (5), 10-oxo-dihydroxy-11β,13-dihydrode hydrocostuslactone (6), (11S)-13-hydroxyl-guaia-4(15),10(14)-diene-12,6α-olide (7), 9-oxonerolidol (8), and vernopolyanthone (9). Conclusion Compounds 1 and 3 are new compounds, named as vlasoudide and vlasoudione; and compounds 4-9 are isolated from the roots of V. souliei for the first time.

国家自然科学基金面上项目（81473413）