目的 建立超高效液相色谱-串联质谱法（UPLC-MS/MS）同时测定中药材中23种植物生长调节剂残留量的分析方法。方法 样品经乙腈提取后无需净化，直接进UPLC-MS/MS分析，用基质匹配标液外标法定量。结果 23种植物生长调节剂在基质中线性关系良好，r均大于0.990，检出限为0.01～20.80 ng/mL。在0.01、0.04、0.1 mg/kg 3个质量分数水平下，空白党参、白芷基质中23种植物生长调节剂的平均回收率为71.0%～101.4%，RSD为0.8%～15.2%。采用该法对8种63批次常用中药材中植物生长调节剂残留情况进行了筛查。结论 该方法前处理简单、快速、灵敏、准确，可用于中药材中植物生长调节剂的残留检测。

Objective To establish an ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the simultaneous determination of 23 plant growth regulator (PGR) residues in Chinese materia medica (CMM). Methods Samples were extracted with acetontrile, and then determined by UPLC-MS/MS directly without further clean up. The matrix-matched external standard method was used for quantitative analysis. Results The calibration curves showed good linearity in each range with correlation coefficients greater than 0.99. The limits of detection (LODs) were 0.01—20.80 ng/mL for the 23 PGRs spiked in Codonopsis pilosula and Angelica dahurica. The recoveries of the 23 PGRs spiked in C. pilosula and A. dahurica at three levels of 0.01, 0.04, and 0.1 mg/kg were in the range of 71.0%—101.4%, the relative standard deviation (RSDs) were 0.8%—15.2%. Commonly used CMM including eight species (63 batches) was analyzed by this method. Conclusion The method proved to be simple, rapid, sensitive, accurate, and suitable for the simultaneous determination of 23 PGR residues in CMM

“十二五”重大新药创制专项课题：中药质量安全检测和风险控制平台（2014ZX09304307-002）