目的 制备芦丁（rutin，Ru）胶态二氧化硅（colloidal silicon dioxide，CSD）固体分散体（Ru-CSD-SD），并对其促进芦丁口服吸收作用进行体内外评价。方法 采用单因素试验考察Ru-CSD-SD制备处方及方法；采用平衡溶解度试验、差示扫描量热（DSC）法（热分析法）及X射线衍射（XRD）法进行表征；通过检测其体外累积溶出率和犬体内血药浓度变化评价Ru-CSD-SD体内外释药行为。结果 经过单因素考察所得Ru-CSD-SD的制备条件：载体为胶态二氧化硅AEROPERL^® 300 pharma（CSD300），药物芦丁与载体CSD300质量比为1：2，方法为溶剂旋蒸法。制备成Ru-CSD-SD后，芦丁平衡溶解度（198.73 mg/L）是原料药（72.69 mg/L）的2.7倍；DSC及XRD法分析表明药物以无定形状态存在于SD中。Ru-CSD-SD在5 min的累积溶出率即达到（82.01±1.04）%。犬口服芦丁普通片剂和Ru-CSD-SD后，t_1/2为1.078、10.899 h，t_max为1.5、0.5 h，Ru-CSD-SD的C_max（103.45 μg/mL）为普通片剂（6.69 μg/mL）的15.46倍，AUC_0~∞（170.406 μg·h/mL）是普通片剂（13.965 μg·h/mL）的12.20倍。结论 以CSD300为载体材料制备Ru-CSD-SD可以增加芦丁溶解度，提高其溶出速率和口服生物利用度。

Objective To prepare the solid dispersion of rutin colloidal silicon dioxide (Ru-CSD-SD) and to promote the rutin oral absorption function, in order to evaluate its in vivo and in vitro oral absorption. Methods Composition and method of Ru-CSD-SD were investigated by single factor test; Equilibrium solubility experiments, differential thermal analysis (DSC), and X-ray diffraction (XRD) were used to determine the Ru-CSD-SD. Cumulative dissolution rates and pharmacokinetic parameters of Ru-CSD-SD were evaluated by drug releasing in vitro and in vivo. Results The preparation conditions of Ru-CSD-SD was selected on the basis of single factor test:Colloidal silicon dioxide AEROPERL^® 300 pharma (CSD300) was used as carrier, the ratio of drug (rutin) and carrier (CSD300) was 1:2, and the method was solvent evaporation. After preparation of Ru-CSD-SD, the equilibrium solubility of rutin increased by 2.7 times from 72.69 to 198.73 mg/L; The DSC and XRD were indicated that rutin existed in the solid dispersions at amorphous form. And cumulative dissolution rates of Ru-CSD-SD reached (82.01±1.04)% in 5 min. After oral administration of rutin ordinary tablets and Ru-CSD-SD, t_1/2 were 1.078, and 10.899 h, t_max were 1.5, and 0.5 h, and Ru-CSD-SD of C_max (103.45 μg/mL) was 15.46 times of ordinary tablets (6.69 μg/mL). Ru-CSD-SD of AUC_0-∞ (170.406 μg·h/mL) was 12.20 times of ordinary tablets (13.965 μg·h/mL). Conclusion The Ru-CSD-SD with CSD300 can increase the solubility, dissolution rate, and bioavailability.