目的 优化栀子炭微波炮制工艺。方法 以HPLC法测定传统炒制方法炮制的栀子炭中京尼平苷及鞣质的量作为评价指标，采用CRITIC法计算权重系数，结合Box-Behnken响应面法，优化栀子炭微波炮制工艺，并对栀子炭微波炮制品的药效进行验证。结果 CRITIC法得出炒制栀子炭京尼平苷、鞣质的权重系数分别为0.27、0.73，微波炮制栀子炭的Box-Behnken响应面法得出最佳工艺为微波功率600 W，微波时间6 min，样品质量120 g，京尼平苷、鞣质量分别为35.19、4.76 mg/g。通过药效验证表明微波炮制栀子炭与传统炒制栀子炭均能够缩短小鼠的出血时间和凝血时间，两者药效无明显区别。结论 微波炮制工艺节能高效、可操作性强，该方法可以作为丰富传统炮制工艺的一种手段和方法。

Objective To determine the index weight and optimize the microwave processing technology of carbonized Gardenia jasminoides (CGJ). Methods The contents of geniposid and tannins in CGJ processed by traditional method were determined by HPLC and used as comprehensive evaluation indexes, the weighting coefficient was determined by CRITIC method, and the microwave processing technology of CGJ was optimized by Box-Behnken response surface methodology (BBRSM). The pharmacological activity of CGJ processed by microwave was also evaluated. Results The weighting coefficients of geniposid and tannins in CGJ processed by traditional method were 0.27 and 0.73. The optimal parameters of microwave processing technology were as follows:microwave power of 600 W, microwave time of 6 min and medicines mass of 120 g, the contents of geniposidic and tannins were 35.19 and 4.76 mg/g. The results of pharmacological evaluation showed that CGJ processed by microwave and traditional method could shorten the bleeding time and clotting time of mice. There was no obvious difference between the two processed products. Conclusion Microwave processing can be used as a processing method to enrich the traditional processing technology.

国家自然科学基金项目（81360620）；江西省教育厅科学技术研究项目（GJJ150846）；江西省卫生计生委中医药科研项目（2015A051，2105A040）