[关键词]
[摘要]
目的 研究黄花獐牙菜Swertia kingii根的化学成分。方法 采用硅胶、Sephadex LH-20等柱色谱法进行分离纯化，并根据化合物理化性质和MS、NMR等波谱数据鉴定其化学结构。结果 从黄花獐牙菜根部95%乙醇提取部位分离得到10个化合物，分别鉴定为去甲基雏菊叶龙胆酮（1）、β-谷甾醇（2）、1，3，7-三羟基（口山）酮（3）、当药醇苷（4）、1，3，7-三羟基-8-甲氧基（口山）酮（5）、1，5，8-三羟基-3-甲氧基<（口山）酮（6）、1，3，7，8-四羟基（口山）酮-1-O-β-D-葡萄糖（7）、1，3，7，8-四羟基（口山）酮（8）、1-羟基-3，7，8-三甲氧基（口山）酮（9）和1，2，6，8-四羟基<（口山）酮（10）。结论 除化合物2外，其余化合物均为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents of the roots of Swertia kingii. Methods The chemical constituents were isolated and purified by silica gel and Sephadex LH-20 chromatographies. Their structures were identified on the basis of physicochemical properties and spectrometric data. Results Ten compounds obtained from this plant were identified as demethylbellidifolin (1), β-sitosterol (2), 1,3,7-trihydro-xanthone (3), swertianolin (4), 1,3,7-trihydrox-8-methoxy-xanthone (5), 1,5,8-trihydroxy-3-methoxy-xanthone (6), 1,3,7,8-tetrahydroxyxanthone-1-O-β-D-glucopyranoside (7), 1,3,7,8-tetrahydroxy-xanthone (8), 1-hydroxy-3,7,8-trimethoxy-xanthone (9), and 1,2,6,8-tetrahydroxy-xanthone (10). Conclusion Except for compound 2, the other compounds are obtained from this plant for the first time.
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[基金项目]
四川省科技支撑计划项目（2015SZ0040）；西南民族大学2015年研究生“创新型科研项目”（CX2015SZ051）
