目的 利用甘蔗镰孢Fusarium sacchari对人参茎叶皂苷进行生物转化。方法 转化产物通过硅胶柱色谱进行分离，经理化常数和光谱分析鉴定化合物的结构。结果 从人参茎叶皂苷的Fusarium sacchari转化产物中分离鉴定了10个化合物，分别为20（S）-人参二醇（1）、20（S）-原人参二醇（2）、20（R）-原人参二醇（3）、20（S）-人参三醇（4）、20（S）-原人参三醇（5）、20（R）-原人参三醇（6）、20（S）-原人参二醇-20-O-β-D-吡喃葡萄糖苷（CK）（7）、人参皂苷F₁（8）、人参皂苷Rh₁（9）和人参皂苷Rg₁（10）。结论 化合物1～10为首次从人参茎叶皂苷的Fusarium sacchari生物转化产物中分离得到，且Fusarium sacchari可转化人参茎叶皂苷生成稀有抗肿瘤皂苷，是一种具有开发价值的稀有活性菌株。

Objective To study the chemical constituents of transformed products by Fusarium sacchari from the leaves saponin of Panax ginseng. Methods Transformation products separated by the process of silica gel column, compounds were identified and elucidated by spectral and chemical methods. Results Ten compounds were isolated from transformed products of Fusarium sacchari from the leaves saponin of P. ginseng and identified as 20 (S)-panaxadiol (1), 20 (S)-protopanoxa-diol (2), 20 (R)-protopanoxa-diol (3), 20 (S)-panaxatriol (4), 20 (S)-protopanaxatriol (5), 20 (R)-protopanaxatriol (6), 20 (S)-protopanoxadiol-20-O-β-D-glucopyranose (7), ginsenoside-F1 (8), ginsenoside Rh₁(9), and ginsenoside Rg₁ (10). Conclusion Compounds 1-10 are the compounds of ginsenosides, isolated from transformed products of F. sacchari from the leaves saponin of P. ginseng for the first time. F. sacchari could transform leaves saponin of P. ginseng to rare antitumor saponin, which is a rare active microbial strain with exploitation value.