目的 对连翘Forsythia suspensa的化学成分进行研究。方法 通过大孔吸附树脂、Sephadex LH-20、反相HPLC等多种色谱进行分离纯化，根据理化性质和波谱数据鉴定化合物结构。结果 从连翘的50%乙醇提取物中分离得到了13个化合物，分别鉴定为毛柳苷（1）、连翘酯苷E（2）、quinolacetic acid（3）、黄瑞烷酮（4）、千里光内酯（5）、cleroindicin C（6）、4-羟基-4-异丙基-1-环己烯甲酸（7）、oleuropeic acid（8）、rel-（1S，2S，4S）-trihydroxy-p-menthane（9）、壬二酸（10）、2-羟基-丁二酸-4-内酯（11）、glochidioboside（12）、（+）-异落叶松脂醇-9-O-β-D-葡萄糖苷（13）。结论 化合物5～13为从连翘属中首次分离得到。

Objective To study the chemical constituents from the fruits of Forsythia suspensa. Methods Compounds were isolated by a combination of various chromatographic techniques including column chromatography over macroporous resin, Sephadex LH-20, and reversed-phase HPLC. Their structures were elucidated by physiochemical property and spectral analysis. Results Thirteen compounds were isolated and identified as salidroside (1), forsythoside E (2), quinolacetic acid (3), rengyolone (4), senecio lactone (5), cleroindicin C (6), 4-hydroxy-4-isopropylcyclohex-1-enecarboxylic acid (7), oleuropeic acid (8), rel-(1S,2S,4S)-trihydroxy-p-menthane (9), azelaic acid (10), 2-hydroxy-succinic acid 4-methylester (11), glochidioboside (12), and (+)-isolariciresino-9-O-β-D-glucopyranoside (13). Conclusion Compounds 5-13 are isolated from genus Forsythia Vahl. for the first time.

2016年哈尔滨商业大学研究团队支持项目（2016TD009）；2016年哈尔滨商业大学青年创新人才支持项目（2016QN074）