目的 研究接骨散对肱骨骨折患者骨代谢的影响。方法 选择128例典型的闭合性肱骨骨折患者为研究对象，分为治疗组和对照组，对照组给予常规抗炎治疗，治疗组在对照组基础上加用接骨散，观察接骨散对骨折后患者骨代谢的改善情况。结果 治疗组能够有效缓解骨折患者的肿胀、疼痛症状，在治疗周期内能够显著提高患者血清骨钙素（OCN）和碱性磷酸酶（ALP）水平、降低D-二聚体水平（P<0.05），但对血清钙水平的影响无统计学意义。结论 接骨散可以通过调节骨折患者的骨代谢而发挥促进骨折愈合的作用，同时通过降低血清D-二聚体水平而改善严重创伤骨折术后血液高凝状态，降低静脉血栓发生的风险。

Objective To study the effect of Jiegusan on bone metabolism in patients with humeral fracture. Methods Totally 128 patients with humeral fracture were divided into the treatment group and control group, and then to observe the influence of Jiegusan on bone metabolism in the patients. Results Symptoms such as swelling and pain in treatment group were significantly improved after treatment with Jigusan than control group. After treatment, serum osteocalcin and alkaline phosphatase in the treatment were significantly higher (P<0.05) and serum D-dimer production was significantly lower than that in the control group, while serum calcium level in serum showed no difference between the experimental and control group. Conclusion Jiegusan can accelerate fracture healing via regulating the bone metabolism and play a role in anticoagulant activity via lowering the level of serum D-dimer.

吉林省医药产业推进计划项目（2040311011YY）