脂质组学是代谢组学的新兴分支学科，亲水作用色谱-质谱联用技术（HILIC-MS）是脂质组学的新型研究手段。通过从生物样本前处理方法，色谱、质谱条件建立及分析全程质控角度，阐明HILIC-MS在脂质组学研究中的应用、操作要点、特殊优势及发展潜力，探讨其在脂代谢疾病中医药临床和科研研究中的应用。

Lipidomics is a new branch discipline of metabolism. The hydrophilic interaction chromatography-mass spectrometry (HILIC-MS) technology is the new study method of lipidomics. The application, operation points, special advantages, and development potential for HILIC-MS were clarified from the angles of biological sample processing method, chromatography, mass spectrometry conditions establishment, and full analysis on quality control. The feasibility of using HILIC-MS technology to solve some lipid metabolism diseases problem in clinical and scientific research of TCM has been investigated.

国家自然科学基金项目（81302882）；广东省科技计划项目（2014A020221118，2014A020221102）；广东省中医药局科研课题（20151303）；广州中医药大学“青年英才”资助项目（QNYC20140106）