目的 优选复方健肾颗粒的提取工艺和制备工艺。方法 建立总皂苷和总多糖的紫外分析方法，通过单因素和正交设计试验，确定最佳提取工艺。考察不同辅料、润湿剂用量，以成型率、溶化性及吸湿率为指标，筛选处方中加入辅料的品种、配比及最佳成型工艺。结果 确定复方健肾颗粒的最佳醇提工艺为10倍量85%乙醇，提取3次，每次2h；最佳水提工艺为14倍量的水，煎煮3次，每次30min。复方健肾颗粒的最佳制备工艺为糊精-乳糖（4∶1），浸膏粉-辅料（1∶1），85%乙醇，用量15%。结论 本实验确定的提取工艺和制备工艺稳定可行，质量可控。

Objective To optimize the extracting and processing conditions of Compound Jianshen Granules (CJG).Methods UV analytical methods of total saponin and total polysaccharides were established, the optimal ethanol extraction process and water extraction process were confirmed according to single factor and orthogonal design test. The influence of different excipients and wetting agents were investigated, taking forming rate, solubility, and absorption rate as indexes, the materials added prescription varieties, ratio, and optimum molding process were screened.Results The optimal ethanol extraction technology of CJG was: 85% ethanol, 10-fold, extracting for three times, 2h once. The optimal water extraction technology was 14-fold, decocting 3 times, 30 min once. The optimized conditions of CJG were obtained with: accessories for the dextrin: lactose (4:1), main drug-accessories (1:1), with 85% ethanol as wetting agent which accounted for 15% of the main drug.Conclusion The extraction process and forming process are feasible and stable, and the quality is controllable.

浙江省自然科学基金资助项目（LY16H280010）