丹参酚酸类成分为丹参治疗心脑血管疾病的主要有效成分，具有显著而确切的生物活性和药理作用。随着临床及市场对丹参酚酸类物质需求量的剧增，提高丹参中酚酸类成分的量及提升利用效率对其可持续发展具有重要意义。基于丹参基因组学、转录组学及代谢组学等方面近年来的研究进展，对丹参酚酸类成分的生物合成途径、关键酶基因与调控机制，以及丹参酚酸类成分生物转化利用现状等进行归纳分析，以期为丹参酚酸类物质资源的高效生产与资源综合利用提供科学依据。

Phenolic acids with significant biological activity and pharmacological effects are a class of active ingredients in the roots and rhizomes of Salvia miltiorrhiza used for the treatment of cardiovascular and cerebrovascular diseases.With increasing the demand of clinical and market,enhancing the contents and utilization efficiency of phenolic acids in the roots and rhizomes of S.miltiorrhiza has the important practical significance for sustainable development.In this paper,the research progress in study on genomics,proteomics,and metabonomics in recent years was carried out to summarize the biosynthesis pathway,key enzymes genes,regulation mechanism,and bioconversion and utilization of phenolic acids in the roots and rhizomes of S.miltiorrhiza,which lays the scientific foundation for the efficient production and comprehensive utilization of phenolic acids resources in S.miltiorrhiza.

江苏省“333高层次人次培养工程”资助项目（BRA2015391）