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首页 > 过刊浏览>2016年第47卷第7期 >2016,47(7):1236-1242. DOI:10.7501/j.issn.0253-2670.2016.07.029
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石菖蒲及其活性成分防治阿尔茨海默病的研究进展

Research progress on Acorus tatarinowii and its active ingredients in treatment of Alzheimer's disease

发布日期：2016-04-01
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    [关键词]
    [摘要]
    中药防治阿尔茨海默病(Alzheimer's disease,AD)是当前人们关注的研究热点。石菖蒲Acorus tatarinowii提取物及其所含化学成分在中枢神经系统可发挥多种药理作用,其中以主要活性部位和化学成分(如挥发油和β-细辛醚等)近年来在改善学习记忆和防治AD方面的报道最多。在查阅相关国内外文献基础之上,概述了石菖蒲提取物及其主要化学成分对AD不同药效作用及其作用机制的研究进展。
    [Key word]
    [Abstract]
    Currently, Chinese materia medica is a research hotspot on the treatment of Alzheimer's disease(AD). The extracts from Acorus tatarinowii have a variety of pharmacological effects on the central nervous system, among which the volatile oil and β-asarone are the main active ingredients in A. tatarinowii reported on the effect on improving the learning and memory and prevention of AD. This review focuses on the main active ingredients in A. tatarinowii and progresses in their different therapeutic effects and proposed pharmacological mechanisms for AD on the basis of referring to the relevant literatures at home and abroad.
    [基金项目]
    天津市应用基础及前沿技术研究计划一般项目"中药抗抑郁作用及其NMDA受体机制研究"(12JCYBJC32400)
    [1] Kosasa T, Kuriya Y, Matsui K, et al. Inhibitory effects of donepezil hydrochloride(E2020) on cholinesterase activity in brain and peripheral tissues of young and aged rats[J]. Eur J Pharmacol, 1999, 386(1):7-13.
    [2] Nussbaum R L, Ellis C E. Alzheimer's disease and Parkinson's disease[J]. N Engl J Med, 2003, 348:1356-1364.
    [3] 刘婧, 付小梅, 吴建华, 等. 中药治疗老年痴呆的研究进展[J]. 中国医药科学, 2014, 4(11):43-46.
    [4] 倪嘉缵, 陈平, 刘琼, 等. 阿尔茨海默病的防治策略研究进展[J]. 深圳大学学报, 2013, 30(4):331-348.
    [5] 叶居新, 何池全. 一种净化水体的植物——石菖蒲[J]. 植物杂志, 1996, 23(1):10-11.
    [6] 吴启端, 吴清和. 石菖蒲的药理研究进展[J]. 中药新药与临床药理, 2006, 17(6):477-480.
    [7] 胡增峣, 黄晏, 刘港, 等. 中药复方治疗老年痴呆的用药规律分析[J]. 中药药理与临床, 2012, 28(5):252-256.
    [8] 林晨, 安红梅, 石菖蒲的中枢神经系统药理作用研究[J]. 长春中医药大学学报, 2014, 30(2):230-233.
    [9] Coleman P D, Yao P J. Synaptic slaughter in Alzheimer's disease[J]. Neurobiol Aging, 2003, 24(8):1023-1027.
    [10] 田素民, 马宇昕, 孙灵芝, 等. 石菖蒲不同药效部位改善阿尔茨海默病模型小鼠的认知功能[J]. 中国病理生理杂志, 2012, 28(1):159-162.
    [11] 马宇昕, 李国营, 孙灵芝, 等. 石菖蒲不同提取部位对β淀粉样蛋白致学习记忆障碍模型小鼠的影响[J]. 神经解剖学杂志, 2011, 27(5):521-526.
    [12] Geng Y, Li C, Liu J, et al. Beta-asarone improves cognitive function by suppressing neuronal apoptosis in the beta-amyloid hippocampus injection rats[J]. Biol Pharm Bull, 2010, 33(5):836-843.
    [13] 张春霞, 郭俊和, 陈云波, 等. 石菖蒲活性成分对双转基因小鼠APP及神经突触超微结构的影响[J]. 中药新药与临床药理, 2014, 25(1):18-23.
    [14] Li Z, Zhao G, Qian S, et al. Cerebrovascular protection of β-asarone in Alzheimer's disease rats:A behavioral, cerebral blood flow, biochemical and genic study[J]. J Ethnopharmacol, 2012, 144(2):305-312.
    [15] 顾丰华, 陈嘉, 许海燕, 等. 石菖蒲水提取物SIPI-SCPd改善动物学习记忆的研究[J]. 世界临床药物, 2012, 33(3):150-155.
    [16] 杨天鹏, 唐敏, 刘巧琼, 等. 丁香酚通过嗅觉通路改善昆明鼠学习记忆的机制[J]. 中国康复医学杂志, 2007, 22(6):487-489.
    [17] Dhivya P, Sobiya M, Selvamani P, et al. An approach to Alzheimer's disease treatment with cholinesterase inhibitory activity from various plant species[J]. Int J Pharm Technol Res, 2014, 6(5):1450-1467.
    [18] Mathew M, Subramanian S. In vitro screening for anticholinesterase and antioxidant activity of methanolic extracts of ayurvedic medicinal plants used for cognitive disorders[J]. PLoS One, 2014, 9(1):e86804.
    [19] 金虹, 徐国波, 黄毅. 石菖蒲抑酶活性的实验研究[J]. 时珍国医国药, 2009, 20(3):2241-2242.
    [20] 吴宾, 方永奇. 石菖蒲益智作用的物质基础及其机理研究[J]. 中医药学刊, 2004, 22(9):1635-1636.
    [21] Wirths O, Multhaup G, Bayer T A. A modified β-amyloid hypothesis:intraneuronal accumulation of the β-amyloid peptide-the first step of a fatal cascade[J]. J Neurochem, 2004, 91(3):513-520.
    [22] Hardy J, Selkoe D J. The amyloid hypothesis of Alzheimer's disease:progress and problems on the road to therapeutics[J]. Science, 2002, 297(5580):353-356.
    [23] Lester-Coll N, Rivera E J, Soscia S J, et al. Intracerebral streptozotocin model of type 3 diabetes:relevance to sporadic Alzheimer's disease[J]. J Alzheimer's Dis, 2006, 9(1):13-33.
    [24] 弓淑娟, 张连巍, 张敏. 神经元谷氨酸转运体的研究进展[J]. 中风与神经疾病杂志, 2012, 29(5):469-472.
    [25] Beart P, O'shea R. Transporters for L-glutamate:An update on their molecular pharmacology and pathological involvement[J]. Br J Pharmacol, 2007, 150(1):5-17.
    [26] Gu Q, Du H, Ma C, et al. Effects of α-asarone on the glutamate transporter EAAC1 in xenopus ocytes[J]. Planta Med, 2009, 75(1):1-4.
    [27] Fusco D, Colloca G, Monaco M R L, et al. Effects of antioxidant supplementation on the aging process[J]. Clin Intervent Aging, 2007, 2(3):377-387.
    [28] Subbarao K V, Richardson J S, Ang L C. Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro[J]. J Neurochem, 1990, 55(1):342-345.
    [29] Smith M A, Harris P L, Sayre L M, et al. Iron accumulation in Alzheimer disease is a source of redox-generated free radicals[J]. Proceed Nat Acad Sci, 1997, 94(18):9866-9868.
    [30] Acuña U M, Atha D E, Ma J, et al. Antioxidant capacities of ten edible North American plants[J]. Phytother Res, 2002, 16(1):63-65.
    [31] Yang Y X, Chen Y T, Zhou X J, et al. Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats[J]. BMC Complement Altern Med, 2013, 13(1):1-6.
    [32] 唐洪梅, 招荣鑑, 邓玉群. 石菖蒲挥发油和水溶性成分对癫痫小鼠脑组织SOD、LPO、NO的影响[J]. 中国药师, 2005, 12(8):983-985.
    [33] Ou H C, Chou F I, Lin T M, et al. Protective effects ofeugenol against oxidized LDL-induced cytotoxicity and adhe-sion molecule expression in endothelial cells[J]. Food Chem Toxicol, 2006, 44(9):1485-1495.
    [34] 江湧, 方永奇, 邹衍衍. β-细辛醚对痴呆小鼠学习记忆能力及SOD、GSH-Px和MDA水平的影响[J]. 中国老年学杂志, 2007(12):1126-1127.
    [35] 王淑英. 老年痴呆的发病机理及药物治疗进展[J]. 洛阳医专学报, 2002, 20(3):266-268.
    [36] Fu S, Fang R, Fang G, et al. Effects of beta-asarone on expression of FOS and GAD65 in cortex of epileptic rat induced by penicillin[J]. 中药材, 2008, 31(1):79-81.
    [37] Zou D J, Wang G, Liu J C, et al. Beta-asarone attenuates beta-amyloid-induced apoptosis through the inhibition of the activation of apoptosis signal-regulating kinase 1 in SH-SY5Y cells[J]. Die Pharmazie-An Int J Pharm Sci, 2011, 66(1):44-51.
    [38] Liu J C, Li C C, Xing G H, et al. Beta-asarone attenuates neuronal apoptosis induced by Beta amyloid in rat hippocampus[J]. Yakugaku Zasshi, 2010, 130(5):737-746.
    [39] Li C, Xing G, Dong M, et al. Beta-asarone protection against beta-amyloid-induced neurotoxicity in PC12 cells via JNK signaling and modulation of Bcl-2 family proteins[J]. Eur J Pharmacol, 2010, 635(1):96-102.
    [40] Wei G, Chen Y B, Chen D F, et al. β-asarone inhibits neuronal apoptosis via the CaMKⅡ/CREB/Bcl-2 signaling pathway in an in vitro model and AβPP/PS1 mice[J]. J Alzheimers Dis, 2013, 33(3):863-880.
    [41] An H M, Li G W, Lin C, et al. Acorus tatarinowii Schott extract protects PC12 cells from amyloidinduced neurotoxicity[J]. Die Pharmazie-An Int J Pharm Sci, 2014, 69(5):391-395.
    [42] 杨立彬, 李树蕾, 黄艳智, 等. 石菖蒲及其有效成分A-细辛醚对癫痫幼鼠脑海马神经元凋亡的影响[J]. 中草药, 2006, 37(8):1196-1199.
    [43] Irie Y, Keung W M. Rhizoma acori graminei and its active principles protect PC-12 cells from the toxic effect of amyloid-β peptide[J]. Brain Res, 2003, 963(1):282-289.
    [44] Booth L A, Tavallai S, Hamed H A, et al. The role of cell signalling in the crosstalk between autophagy and apoptosis[J]. Cell Signal, 2014, 26(3):549-555.
    [45] 佳娜提·达吾列提, 姜楠, 寇俊萍, 等. 调节细胞自噬的中药有效成分研究进展[J]. 中草药, 2014, 45(16):2283-2292.
    [46] Arroyo D S, Gaviglio E A, Ramos J M. P, et al. Autophagy in inflammation, infection, neurodegeneration and cancer[J]. Int Immunopharmacol, 2014, 18(1):55-65.
    [47] 刘知学, 陈洁, 张德翼. 细胞自噬的调控机制及其在老年性痴呆发生发展中的作用[J]. 生物化学与生物物理进展, 2012, 39(8):726-733.
    [48] 苏方, 张培, 姜治伟, 等. 海马神经元缺血/再灌注后自噬的表达及其作用[J]. 中国应用生理学杂志, 2011, 27(2):187-191.
    [49] Mo Z T, Fang Y Q, He Y P, et al. β-Asarone protects PC12 cells against OGD/R-induced injury via attenuating Beclin-1-dependent autophagy[J]. Acta Pharmacol Sin, 2012, 33(6):737-742.
    [50] Xue Z, Guo Y, Zhang S, et al. Beta-asarone attenuates amyloid beta-induced autophagy via Akt/mTOR pathway in PC12 cells[J]. Eur J Pharmacol, 2014, 741:195-204.
    [51] Liu L, Fang Y Q, Xue Z F, et al. Beta-asarone attenuates ischemia-reperfusion-induced autophagy in rat brains via modulating JNK, p-JNK, Bcl-2 and Beclin 1[J]. Eur J Pharmacol, 2012, 680(1):34-40.
    [52] Dai J P, Zhao X F, Zeng J, et al. Drug screening for autophagy inhibitors based on the dissociation of Beclin1-Bcl2 complex using BiFC technique and mechanism of eugenol on anti-influenza A virus activity[J]. PLoS One, 2013, 8(4):e61026.
    [53] Hock C, Heese K, Hulette C, et al. Region-specific neurotrophin imbalances in Alzheimer disease:decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas[J]. Archiv Neurol, 2000, 57(6):846-851.
    [54] Kunugi H, Ueki A, Otsuka M, et al. A novel polymorphism of the brain-derived neurotrophic factor(BDNF) gene associated with late-onset Alzheimer's disease[J]. Mol Psychiatry, 2001, 6(1):83-86.
    [55] 徐凯, 卫东锋, 张仰君, 等. 知母及其提取物改善学习记忆和治疗阿尔茨海默病研究进展[J]. 中国中医药信息杂志, 2014, 21(6):132-136.
    [56] Limón I D, Mendieta L, Díaz A, et al. Neuroprotective effect of alpha-asarone on spatial memory and nitric oxide levels in rats injected with amyloid-β(25-35)[J]. Neurosci Lett, 2009, 453(2):98-103.
    [57] 刘扬俊, 邱腾颖. 石菖蒲微波水提液的抗炎及体外抗菌作用研究[J]. 海峡药学, 2012, 24(6):22-23.
    [58] 吴晶晶, 黄开远, 黎晖, 等. β-细辛醚抑制核转录因子Kappa B表达[J]. 解剖学研究, 2012, 34(2):104-106.
    [59] 陶莉, 望运玲, 武双婵, 等. 丁香酚对大鼠局灶性脑缺血/再灌注神经保护作用的研究[J]. 中国药理学通报, 2013, 29(8):1146-1150.
    [60] 江湧, 方永奇, 何玉萍. 石菖蒲有效成分配伍对Aβ损伤PC12细胞的保护作用[J]. 中药新药与临床药理, 2006, 17(5):335-338.
    [61] 殷明. 阿尔茨海默病治疗药物研发全面受挫及其思考[J]. 药学学报, 2014, 49(6):757-763.
    [62] Liu L, Fang Y Q. Analysis of the distribution of β-asarone in rat hippocampus, brainstem, cortex and cerebellum with gas chromatography-mass spectrometry(GC-MS)[J]. J Med Plants Res, 2011, 5(9):1728-1734.
    [63] 段灿灿, 许建阳, 陈牛艳, 等. 益智饮对阿尔茨海默病大鼠学习记忆能力的影响及抗氧化作用[J]. 中国实验方剂学杂志, 2010, 16(5):135-138.
    [64] 田会娟. 石菖蒲组分配伍治疗鹅膏蕈氨酸致痴呆大鼠的药效学研究[D]. 广州:广州中医药大学, 2012.
    [65] 姜静, 邓扬鸥, 杨丽. β-细辛醚, 丁香酚和远志皂苷对Aβ25-35神经细胞毒性的保护作用[J]. 中药药理与临床, 2012, 28(5):25-28.
    [66] Hu B, Zhang H, Meng X, et al. Aloe-emodin from rhubarb(Rheum rhabarbarum) inhibits lipopolysaccharide- induced inflammatory responses in RAW264. 7 macrophages[J]. J Ethnopharmacol, 2014, 153(3):846-853.
    [67] 张博, 黄树明. 开心散治疗老年性痴呆的研究进展[J]. 中药药理与临床, 2013, 29(3):193-196.
    [68] 林慧光, 杜建, 张亮亮, 等. 石菖蒲挥发油香熏辅助治疗老年性痴呆大鼠的实验研究[J]. 福建中医学院学报, 2007, 17(4):25-27.
    [69] 应侠, 吴振, 雷严, 等. 阿尔茨海默病的发病机制及治疗药物研究进展[J]. 中国药房, 2014, 25(33):3152-3155.
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