四君子汤为中医健脾益气的代表方剂,由人参、白术、茯苓、炙甘草4味药组成,具有调节胃肠道功能、增强免疫力、促进癌细胞凋亡、抗衰老作用,其主要化学成分为皂苷、黄酮和多糖,该方多糖成分、药效物质基础研究较少。总结了四君子汤的化学成分、药理作用研究进展,为深入研究四君子汤及其临床的合理应用提供参考。

Sijunzi Decoction(SJZD) is a classical prescription for curing spleen deficiency in traditional Chinese medicine, consisting of Ginseng Radix et Rhizoma, Atractylodes Macrocephalae Rhizoma, Poria, and Glycyrrhizae Radix et Rhizoma Praeparate cum Melle.Modern pharmacological experiments have proved that sponin, flavonoid, and polysaccharide are the most active ingredients in SJZD.SJZD has been used to regulate gastrointestinal function and enhance immunity ability.Effects on tumor cell apoptosis and anti-aging have also been reported.But few report on SJZD polysaccharide and its therapeutic basis research was found.This review is to give a comprehensive summary of information regarding the chemical constituents and pharmacological effects of SJZD to help us take the action for reasonable clinical utilization and further researches of SJZD.

国家自然科学基金资助项目:四君子汤多糖的肠道菌群介导免疫作用发挥机制及物质基础研究(81473318);四君子汤药效作用物质群及其相关功能菌组的研究(30973962)