二氢杨梅素是植物显齿蛇葡萄中主要的黄酮类化合物,近年来其药理作用和制剂工艺受到业界广泛的关注。二氢杨梅素药理作用确切,但其自身理化性质和生物利用度低限制了该药物的临床应用,研究制剂新技术与新剂型改善其理化性质已逐渐成为研究的热点。通过查阅国内外相关文献,综述了近年来二氢杨梅素制剂新技术与新剂型如脂质体、微囊、微乳、固体分散体、包合物、胃漂浮制剂等的研究进展,指出目前研究的不足,为今后研究提供参考。

As a major flavonoid in the leaves of Ampelopsis grossedentata, dihydromyricelin has attracted wide attention in recent years. The pharmacological effect of the dihydromyricelin is clear, but the limitation on the clinical application of this drug comes from its chemical properties and low bioavailability. Nowadays, researching on advanced pharmaceutical preparation and new dosage forms in order to improve its chemical properties has become hot spots. Based on the review of related literatures, we discussed the research progress on advanced pharmaceutical preparation and new dosage forms of dihydromyricelin, such as liposomes, microcapsules, microemulsions, solid dispersion, inclusion compound, floating gastroretentive drug, etc. The main purpose is to point out the shortages of existing research and provide a reference for further study.

国家自然青年科学基金资助项目(81503013);华中科技大学创新研究院技术创新基金(CXY13Q059)