目的 研究猫眼草Euphorbia lunulata的化学成分。方法 利用硅胶、凝胶等柱色谱法进行分离和纯化,通过理化性质和核磁共振波谱进行化合物的结构鉴定。结果 从猫眼草90%乙醇提取物中分离得到了17个化合物,分别鉴定为正二十八烷醇(1)、β-谷甾醇(2)、咖啡酸十八烷酯(3)、cycloart-23Z-en-3β,25-diol(4)、东莨菪素(5)、24-亚甲基环阿尔廷醇(6)、豆甾醇(7)、短叶苏木酚(8)、o-phthalic acid bis-(2-ethyl decyl)-ester(9)、阿魏酸二十六烷酯(10)、东莨菪素苷(11)、β-香树脂醇(12)、没食子酸(13)、蔗糖(14)、17-羟基-岩大戟内酯A(15)、岩大戟内酯A(16)、岩大戟内酯B(17)。结论 化合物1、3、8~12、14~17均为首次从该植物中分离得到,化合物9为首次从大戟属中分离得到。

Objective To study the chemical constituents in the whole herb of Euphorbia lunulata. Methods The compounds were separated and purified by silica gel and Sephadex LH-20 column chromatography. The structures of the compound were identified on the basis of chemical and spectral methods. Results Seventeen compounds were isolated from 90% ethanol extract from the whole herbs of E. lunulata and identified as 1-octacosanol (1), β-sitosterol (2), octadecyl caffeate (3), cycloart-23Z-en-3β,25-diol (4), scopoletion (5), 24-methylenecycloartanol (6), stigmasterol (7), vifolin (8), o-phthalic acid bis-(2-ethyl decyl)-ester (9), ferulic acid hexacosyl ester (10), scopoletin-7-glucoside (11), β-amyrin (12), gallic acid (13), sucrose (14), 17-hxdroxyjolkinolide A (15), jolkinolide A (16), and jolkinolide B (17). Conclusion Compounds 1, 3, 8-12 and 14-17 are isolated from this plant for the first time, and compound 9 is isolated from the plants of Euphorbia L. for the first time.