目的 优选心神宁片的最优提取工艺条件。方法 以干膏率及栀子苷、斯皮诺素的转移率为评价指标,以Plackett- Burnman设计联合Box-Behnken设计-效应面法对心神宁片的提取工艺进行考察,确定最优提取工艺参数。结果 最优提取工艺为7.5倍量70%乙醇,回流提取3次,每次1.5 h。结论 优选的醇提工艺经中试验证合理可行,可以用于工业大生产。

Objective To optimize the extraction process for Xinshenning Tablets. Methods The extracting condition was optimized by Plackett-Burnman, Box-Behnken, and response surface methodology with the extraction rate, geniposide, and spinosin as indexes. Results The optimal extracting condition was extracting 3 times with 7.5 fold 70% alcohol, 1.5 h for each time. Conclusion The optimized process condition is simple and feasible. It can be used in the production.