目的 利用响应面法优选天麻产地加工的一体化工艺。方法 采用Box-Behnken中心组合设计方法对一体化加工工艺中蒸制时间、干燥温度和干燥时间3个因素进行考察,以天麻中5个指标性成分天麻素及巴利森苷A、B、C、E质量分数的综合评分作为考察指标进行产地加工一体化工艺优化研究。结果 最佳一体化加工工艺为蒸制30 min,60 ℃干燥12 h。结论 响应面法优选天麻产地加工一体化工艺简便易行,准确度较好,为中药饮片生产提供了科学的依据和新颖的思路。

Objective To optimize the integrative technology of primary processing for Gastrodiae Rhizoma by response surface methodology. Methods The single factor experiment combined with Box-Behnken design was used to optimize the integrative technology, with five major characteristic components (gastrodin, parishin A, parishin B, parishin C, and parishin E) as indexes, in order to detect three factors (steaming time, drying time, and drying temperature), and optimize the primary processing of Gastrodiae Rhizoma. Results Optimum percolation process was as follows: Gastrodiae Rhizoma was steamed for 30 min, and dried for 12 h at 60 ℃. Conclusion This optimized integrative technology of Gastrodiae Rhizoma is reasonable and feasible, and with high accuracy. It could provide the scientific basis and innovative idea to the large-scale production of decoction pieces of Chinese Materia Medica.

江苏省中药资源产业化过程协同创新中心项目(ZDXM-1-3);江苏高校优势学科建设工程资助项目(PAPD)