目的 研究我国特有药用植物猕猴桃藤山柳Clematoclethra scandens subsp. actinidioides的化学成分。方法 采用各种柱色谱及制备液相色谱分离纯化,经理化性质和波谱数据鉴定化合物结构。结果 从猕猴桃藤山柳茎叶甲醇提取物中分离得到19个化合物,分别鉴定为夏枯草皂苷A(1)、9-hydroxy-megastigma-4,7-dien-3-one-9-O-β-D-glucopyranoside(2)、山柰酚-3-O-α-L-吡喃鼠李糖苷(3)、槲皮素-3-O-α-L-吡喃鼠李糖苷(4)、槲皮素-3-O-β-D-吡喃葡萄糖苷(5)、金丝桃苷(6)、1,3,6-三-O-没食子酰-β-D-吡喃葡萄糖苷(7)、1,2,3,6-四-O-没食子酰-β-D-吡喃葡萄糖苷(8)、儿茶素(9)、棓儿茶素(10)、原花青素B3(11)、原儿茶酸(12)、丁香酸(13)、香草酸(14)、7-羰基贝壳杉烯内酯(15)、豆甾-3,6-二酮(16)、豆甾-4-烯-3,6-二酮(17)、蒲公英赛烷醇(18)、β-谷甾醇(19)。结论 化合物1～12、16为首次从该属植物中分离得到。

Objective To further study the chemical constituents of Clematoclethra scandens subsp. actinidioides. Methods The compounds were isolated and purified by chromatographic methods such as silica gel column chromatography and preparative HPLC, and their structures were identified on the basis of physicochemical properties and spectral data. Results Nineteen compounds were isolated and identified as vulgarsaponin A (1), 9-hydroxy-megastigma-4,7-dien-3-one-9-O-β-D-glucopyranoside (2), kaempferol-3-O- α-L-rhamnpyranoside (3), quercetin-3-O-α-L-rhamnopyranoside (4), quercetin-3-O-β-D-glucopyranoside (5), hyperoside (6), 1,3,6-tri-O-galloyl-β-D-glucopyranoside (7), 1,2,3,6-tetra-O-galloyl-β-D-glucopyranoside (8), catechin (9), gallocatechin (10), procyanidin B3 (11), protocatechuic acid (12), syringic acid (13), vanillic acid (14), 7-oxokaurenolide (15), stigmast-3,6-dione (16), stigmast-4-en-3,6-dione (17), taraxerol (18), and β-sitosterol (19). Conclusion Compounds 1—12, and 16 are isolated from the plant of Clematoclethra Maxim. for the first time.

国家自然科学基金资助项目(21302180、21572219、21572221、31560102)