目的 研究粉萆薢(粉背薯蓣Dioscorea hypoglauca干燥根茎)中的脂溶性化学成分。方法 采用色谱法分离纯化化合物,理化性质和波谱数据鉴定化合物结构。结果 从粉萆薢脂溶性部分中分离鉴定了13个化合物,包括3个二芳基庚烷类和一些其他类化合物,分别鉴定为7-(4-羟基-3-甲氧基苯基)-1-(4-羟基苯基)-4,6-庚烷-3-酮(1)、1,7-双-(4-羟基苯基)-1,4,6-庚三烯-3-酮(2)、1,7-双-(4-羟基苯基)-4,6-庚二烯-3-酮(3)、大黄素(4)、7-羟基-2,6-二甲氧基-1,4-菲醌(5)、薯蓣皂苷元(6)、鲁可斯皂苷元(7)、山柰酚(8)、(3S)-6,8-二羟基-3-苯基-3,4-二氢异香豆素(9)、5-羟甲基糠醛(10)、β-谷甾醇(11)、豆甾醇(12)、二十六烷酸(13)。结论 化合物4、5、7、8、12、13为首次从粉萆薢中分离得到,化合物1、10为首次从薯蓣属植物中分离得到。

Objective To study the liposoluble constituents from the rhizome of Dioscoreae hypoglaucae. Methods The chemical constituents were isolated and purified by chromatographys and the structures were analyzed and identified by physicochemical properties and spectroscopic data. Results Thirteen compounds including three diarylheptonoids and other types were isolated from the rhizome of D. hypoglaucae, and their structures were elucidated as tsaokoarylone (1), 1,7-bis (4-hydroxyphenyl)-4,6- heptabien-3-one (2), 1,7-bis (4-hydroxyp henyl)-1,4,6-heptatrien-3-one (3), emodin (4), 7-hydroxy-2,6-dimethoxy-1,4- phenanthrenequinone (5), diosgenin (6), ruscogenin (7), kaempferol (8), 3S-6,8-dyhydroxy-3-phenyl-3,4-dihydroisocoumarins (9), 5-hydroxymethylfurfural (10), β-sitosterol (11), stigmasterol (12), and hexacosanoic acid (13). Conclusion Compounds 4, 5, 7, 8, 12 and 13 are isolated from the rhizome of D. hypoglaucae for the first time. Compounds 1 and 10 are isolated from the species of Dioscoreaceae for the first time.

北京中医药大学科研创新团队项目(2011-CXTD-12)