通过检索国内外数据库,收集近10年来国内外针对苦参凝胶与甲硝唑的随机对照试验(RCT),根据纳入和排除标准,提取有效数据并利用Rev Man5.0软件进行荟萃分析。系统评价苦参凝胶与甲硝唑治疗细菌性及滴虫性阴道炎有效性与安全性。共初检出63篇文献,经筛选最终纳入4篇RCT进行荟萃分析,苦参凝胶组与甲硝唑组相比改善阴道炎症状的作用更明显 [RR＝1.13,95% CI(1.06,1.20),P<0.01];苦参凝胶组较甲硝唑组不良反应事件发生率更低 [RR＝0.29,95% CI(0.15,0.56),P<0.01]。苦参凝胶比甲硝唑更能有效缓解阴道炎症,不良事件发生率较后者低。

Related randomly controlled trials about Kushen Gel and Metronidazole in recent 10 years were collected by various kinds of database according to strict inclusion and exclusion criteria. Valid data were extracted to conduct Meta-analysis by RevMan5.0. To evaluate the efficacy and safety of Kushen Gel and Metronidazole for bacterial and trichomonas vaginitis. A total of 63 articles were retrieved, but only four of them were finally included. Meta-analysis showed that the effective proportion of Kushen Gel was significantly higher than that of Metronidazole [RR = 1.13, 95% CI (1.06 and 1.20), P < 0.01]. The incidence of adverse effects was significantly lower in Kushen group compared to the Metronidazole group [RR = 0.29, 95% CI (0.15 and 0.56), P < 0.01]. Kushen Gel can improve symptoms of vaginitis more effectively than Metronidazole and tend to have lower incidence of adverse effects.