随着现代科技的飞速发展,新型高分子材料不断涌现,多学科知识的融合使中药新型给药系统的研究取得了较大进展.与传统制剂相比,新型给药系统药物体内分布具有较高的选择性,血药浓度与药效的关联度不明显,有必要对其在效应局部靶组织中的动力学过程进行较为系统的研究.综述了中药新型给药系统局部药动学研究的技术方法和发展现状,并探讨了其所面临的问题和挑战.

With rapid development of modern science and technology, much progress has been made in novel drug delivery system of Chinese materia medica (CMM), combined with new polymer materials and multidisciplinary knowledge. Compared with the traditional preparation, novel drug delivery system in drug distribution in vivo presented high selectivity. In addition, there was no clear correlation between drug concentration in blood and efficacy. Pharmacokinetic process in local target in effect should therefore be systematically investigated. In this article, the author reviewed the means and technology of local pharmacokinetic study on novel drug delivery system for CMM, as well as progress made, and further discussed the developmental issues and challenges.

国家自然科学基金重点项目(81430096)