目的 研究蒙药多叶棘豆Oxytropis myriophy全草的化学成分.方法 采用硅胶柱色谱、Sephadex LH-20柱色谱和薄层色谱等方法分离纯化,根据理化性质和波谱数据鉴定其结构.结果 从多叶棘豆全草氯仿和醋酸乙酯萃取物分离得到11个化合物,分别鉴定为5-羟基-7,4'-二甲氧基黄酮(1)、4-羟基苯乙酮(2)、5,4'-二羟基-7,3'-二甲氧基黄酮(3)、5,7-二羟基-6,4'-二甲氧基黄酮(4)、异鼠李素(5)、山柰酚(6)、苯乙酮-4-O-β-D-葡萄糖苷(7)、2-羟基-6-甲氧基苯乙酮-4-O-β-D-葡萄糖苷(8)、6-甲氧基香豆素-7-O-β-D-葡萄糖苷(9)、异鼠李素-3-O-β-D-葡萄糖苷(10)、山柰酚-3-O-β-D-葡萄糖苷(11).结论 11个化合物均首次从该植物中分离得到,其中化合物1、7、8为首次从棘豆属植物中分离得到.

Objective To study the chemical constituents of CHCl₃ and EtOAc extracts from Oxytropis myriophy. Methods The CHCl₃ and EtOAc extracts of O. myriophy were isolated and purified by silica gel chromatography, Sephadex LH-20, and PTLC chromatography. The structures were identified by spectral methods. Results Eleven compounds were obtained and identified from the CHCl₃ and EtOAc extracts from O. myriophy, namely 5-hydroxyl-7,4'-dimethoxyflavone (1), 4-hydroxylacetophenone (2), 5,4'-dihydroxyl-7,3'-dimethoxyflavone (3), 5,7-dihydroxyl-6,4'-dimethoxyflavone (4), isorhamnetin (5), kaempferol (6), acetophenone- 4-O-β-D-glucoside (7), 2-hydroxyl-6-methoxyacetophenone-4-O-β-D-glucoside (8), 6-methoxycoumarin-7-O-β-D-glucoside (9), isorhamnetin-3-O-β-D-glucoside (10), and kaempferol-3-O-β-D-glucoside (11). Conclusion All of the compounds are isolated from this plant for the first time and compound 1, 7, and 8 are isolated from the plants of Oxytropis DC. for the first time.

内蒙古自然科学基金面上项目(2013MS1218);内蒙古自治区高等学校科学技术研究项目(NJZY13158)