白附子为天南星科犁头尖属植物独角莲Typhonium giganteum的干燥块茎,临床上多用于治疗肿瘤、中风、三叉神经痛、面瘫等,但其具体的药效、毒性成分及药理机制尚不明确。通过对国内外文献研究与分析,对白附子的本草考证及药典沿革、化学成分、药理毒理作用、炮制工艺、质量控制等方面进行了较全面的综述,为合理开发白附子药用价值提供参考。

Typhonii Rhizoma, the dried tuber of Typhonium giganteum, is a kind of commonly used Chinese materia medica for the treatment of cancer, stroke, trigeminal neuralgia, facial paralysis, and many other illnesses, but its active and toxic components as well as molecular mechanisms have not been specified. In this paper, the herbal textual research, historical evolutions in Pharmacopoeia, chemical composition, pharmacology and toxicology, processing and quality control of Typhonii Rhizoma were summarized in detail, so as to provide the references for the rational development and utilization of Typhonii Rhizoma.

国家"十二五"重大新药创制专项(2014ZX09304307-002)