目的 研究糙叶败酱Patrinia scabra根及根茎的化学成分。方法 利用大孔吸附树脂、硅胶及Sephadex LH-20凝胶柱色谱对其化学成分进行分离、纯化, 根据理化性质及波谱数据进行结构鉴定。结果 从糙叶败酱水提取物的正丁醇萃取部位分离得到12个化合物, 分别鉴定为5-O-阿魏酰奎宁酸(1)、7α-莫诺苷(2)、7β-莫诺苷(3)、白花败酱醇(4)、原儿茶酸(5)、β-胡萝卜苷(6)、isopatriscabroside I(7)、patriscabroside I(8)、patrinioside(9)、松脂醇-4,4'-二-O-β-D-葡萄糖苷(10)、落叶松脂醇-4'-O-β-D-葡萄糖苷(11)、villosolside(12)。结论 糙叶败酱正丁醇部位以环烯醚萜类化合物居多, 其中, 化合物2～6为首次从该植物中分离得到, 化合物1为首次从败酱科败酱属植物中分离得到。

Objective To study the chemical constituents of ethyl acetate fraction from Patrinia scabra. Methods Chemical constituents were isolated and purified by macroporous resin, silica gel, and Sephadex LH-20 column chromatography. Their structures were elucidated on the basis of spectroscopic analysis and chemical evidence. Results Twelve compounds were isolated and purified. Their structures were identified as 5-O-feruloylquinic acid (1), 7α-morroniside (2), 7β-morroniside (3), villosol (4), protocatechuic acid (5), β-daucosterol (6), isopatriscabroside I (7), patriscabroside I (8), patrinioside (9), pinoresinol-4,4'-di-O-β-D-glucopyranoside (10), lariciresinol-4'-O-β-D-glucopyranoside (11), and villosolside (12). Conclusion Compounds 2—6 are isolated from this plant for the first time and the compound 1 is isolated from the plants of Patrinia Juss. (Valerianaceae) for the first time.

甘肃省中药药理与毒理学重点实验室开放课题(ZDSYS-KJ-2013-001);甘肃省医学科学研究院中青年科技人才创新工程项目(ykz-2013-3)