目的 探讨凉血化斑颗粒治疗银屑病的作用机制及临床疗效。方法 采用雌激素周期小鼠阴道上皮有丝分裂模型、小鼠尾部鳞片表皮颗粒层形成模型, 观察凉血化斑颗粒给药后的变化以确定其药理作用。同时, 临床中选取100例银屑病患者, 随机分为两组, 治疗组和对照组各50例。治疗组口服凉血化斑颗粒, 1次1袋, 1日3次。对照组服用凉血化斑组方汤剂, 1日1剂, 水煎分早晚2次口服。两组疗程均为4个月, 随访6个月, 观察比较两组疗效、银屑病面积及严重程度指数(PASI评分)情况并采用SPSS 19.0软件进行统计分析。结果 凉血化斑颗粒能抑制雌激素周期小鼠阴道上皮有丝分裂、促进小鼠尾部鳞片表皮颗粒层的形成。临床观察中, 治疗组总有效率为88.00%, 对照组为90.00%, 在降低PASI评分及疗效指数方面, 两组不存在显著性差异。结论 凉血化斑颗粒具有改善和逆转小鼠银屑病病理模型的作用;其治疗银屑病的临床疗效确切, 且具有服用方便、质量稳定等优点, 在临床上具有一定的应用价值。

Objective To investigate the pharmacological and clinical effects of Liangxue Huaban Granule in the treatment of psoriasis. Methods The models of vaginal epithelium cell mitosis and scaled tail epidermis in mice with estrogen cycle were used to observe the changes of mice after administration of Liangxue Huaban Granule so as to study its pharmacological effects. Meanwhile, 100 cases of patients with psoriasis were chosen and randomly divided into two groups, treatment group and control group, there were 50 cases in each group respectively. The patients in the treatment group were given Liangxue Huaban Granule orally, one bag each time and three times daily. The patients in the control group were given the decoction of Liangxue Huaban components orally, one dose with decocting water, half dose in the morning and evening, respectively. Both two groups had four months treatment, six months post visiting, in order to observe and compare the effects of the two groups and PASI grades which were statistically analyzed by SPSS 19.0. Results Liangxue Huaban Granule could inhibit the mitosis of mouse vaginal epithelia and promote the formation of cuticular granular cells on scaled epidemis of mouse tail. In the clinical observation, the total effective rates in the treatment group and the control group are 88.00% and 90.00%, respectively. And there is no significant difference in lowering the severity index of psoriasis (PASI grades) and curative effect index between two groups. Conclusion The Liangxue Huaban Granule can effectively improve and reverse the pathological model of psoriasis in mice. It has the definite clinical effects of curing psoriasis, And it is convenient to take and has stable quality. In addition, Liangxue Huaban Granule has certain clinical application value.

吴阶平医学基金会临床科研专项资助基金(320.6750.11016)