目的 探讨厚朴中小分子化合物厚朴酚与和厚朴酚对鼻咽癌细胞增殖、迁移、侵袭的影响.方法 分别采用MTT比色法、细胞划痕实验、Transwell实验,观察厚朴酚与和厚朴酚对鼻咽癌细胞HONE1增殖、迁移、侵袭的影响.结果 厚朴酚与和厚朴酚对鼻咽癌细胞HONE1有较显著的抑制增殖、迁移和侵袭效应,而且这种效应呈显著的剂量依赖性.结论 厚朴酚与和厚朴酚能够抑制鼻咽癌肿瘤细胞增殖、迁移和侵袭,厚朴酚与和厚朴酚是具有开发潜力的抗癌小分子化合物.

Objective To investigate the mechanism of small molecules (magnolol and honokiol) in Magnolia officinalis in the proliferation, migration, and invasion of nasopharyngeal carcinoma cells. Methods The effects of magnolol and honokiol on proliferation, migration, and invasion of nasopharyngeal carcinoma cells HONE1 were observed using MTT assay, cell scratch assay, and Transwell assay. Results The proliferation, migration, and invasion of nasopharyngeal carcinoma cell HONE1 were significantly restrained by magnolol and honokiol and this effect was prominently dose-dependent. Conclusion Magnolol and honokiol could inhibit the proliferation, migration, and invasion of nasopharyngeal carcinoma cells, and are small molecules with development potential of anticancer.

国家自然科学基金资助项目(81100471,81270748);深圳市科技计划项目(201302042,201302043);深圳市科技研发资金基础研究计划资助项目(JCYJ20130402114702127,JCYJ20120827150357364)