目的 研究赤芝Ganoderma lucidum子实体的化学成分。方法 利用硅胶柱色谱、凝胶柱色谱、制备液相色谱等方法进行分离、纯化，根据化合物的理化性质和波谱数据鉴定其结构。结果 从赤芝子实体80%乙醇提取物醋酸乙酯萃取部位分离得到6个化合物，分别鉴定为赤芝酸B甲酯（1）、赤芝酸K甲酯（2）、赤芝酸A甲酯（3）、赤芝酸F甲酯（4）、2，4，5-三羟基苯甲醛（5）、2，5-二羟基苯甲酸（6）。结论 化合物1为新的三萜类化合物，化合物5为首次从灵芝属中分离得到，化合物6为首次从赤芝中分离得到。

Objective To study the chemical constituents in the dried fruiting body of Ganoderma lucidum. Methods The constituents were separated and purified by silica gel, Sephadex LH-20 column chromatography, and preparative HPLC. The structures were identified by physicochemical properties and spectral analyses. Results Six compounds were obtained from the ethyl acetate fraction of 80% ethanol extract of G. lucidum and identified as methyl lucidente B (1), methyl lucidente K (2), methyl lucidente A (3), methyl lucidente F (4), 2, 4, 5-trihydroxybenzaldehyde (5), and 2, 5-dihydroxybenzoic acid (6). Conclusion Compound 1 is a new compound, compound 6 is found from the fruiting body of G. lucidum for the first time, and compound 5 is first found from the genus Ganoderma Karst.