目的 研究龙胆科植物川东獐牙菜Swertia davidi干燥全草的化学成分。方法 采用硅胶柱色谱、凝胶色谱等方法进行化学成分的分离纯化，通过理化性质和波谱数据进行结构鉴定。结果 从川东獐牙菜全草70%乙醇提取物中分离得到16个化合物，分别鉴定为熊果醇（1）、齐墩果酸（2）、5-羧基-3, 4-二氢-1H-2-苯并吡喃-1-酮（3）、3β, 12β-二羟基-孕烷-16-烯-20-酮（4）、当药黄素（5）、日当药黄素（6）、异金雀花素（7）、6-去甲氧基-7-甲基茵陈色原酮（8）、3-乙酰氧基-28-羟基-12-烯-乌苏烷（9）、龙胆苦苷（10）、N-正二十五烷-2-羧基苯甲酰胺（11）、4-O-2-羟基-6-甲氧基苯乙酮苷（12）、槲皮素- 3-O-β-D-木糖-(1→2)-β-D-半乳糖苷（13）、8-表金吉苷（14）、3, 5-二咖啡酰奎宁酸（15）、2-甲基苯基-1-O-β-D-吡喃葡萄糖苷（16）。结论 所有化合物均为首次从该植物中分离得到。

Objective To study the chemical constituents from the whole plant of Swertia davidi. Methods The chemical constituents were isolated and purified with silica gel column chromatography, silica gel chromatography, etc. The structures of the compounds were identified by physicochemical properties and various spectroscopic methods. Results Sixteen compounds were isolated as uvaol (1), oleanolic acid (2), 5-carboxyl-3, 4-dihydrogen-1H-2-benzopyran-1-one (3), 3β, 12β-pregnane-16-12-ene-20 (4), swertisin (5), 6-C-β-glucopyranosyl-7-O-methylluteolinidin (6), isoscoparin (7), 6-demethoxy-7-methylcapillarisin (8), 3- acetoxy-28-hydro-xyl-12-eneurs (9), gentiopicroside (10), N-pentacosy-2-carboxy-benzoylamide (11), 4-O-glycosyloxy-2-hydroxy- 6-methoxy-acetophenone (12), quercetin-3-O-β-D-xylopyranosyl-(1→2)-β-D-galactopyranoside (13), 8-epikingiside (14), 3, 5- dicaffeoylquinicacid (15), and 2-methylphenyl-1-O-β-D-glucopyranoside (16). Conclusion All the compounds are isolated from S. davidi for the first time.

湖南省重点建设学科经费资助（2011-42）；民族药用植物活性成分高效利用湖南省高校创新团队经费资助（2010-53）