目的 对不同来源的肉苁蓉药材进行分析，为肉苁蓉药材的质量控制及采收加工提供依据。方法 采用HPLC-UV方法，对肉苁蓉药材中的松果菊苷和毛蕊花糖苷进行测定；采用HPLC-ELSD法对肉苁蓉药材中半乳糖醇进行测定。基于3种活性成分质量分数的差异，对来源于我国内蒙古、新疆以及宁夏地区的68批肉苁蓉药材进行了分析，以期阐明不同产地、不同加工方法、不同生长期及空间搭载等因素对肉苁蓉药材中活性成分的影响。结果 不同来源肉苁蓉药材活性成分量差异较大，产地以内蒙古和新疆等道地产地药材活性成分量较高；加工方法对肉苁蓉药材不同活性成分量影响不同，松果菊苷和毛蕊花糖苷以切片杀酶的方法为佳，半乳糖醇以直接干燥的方法为佳；不同生长期的肉苁蓉药材活性成分量为花序未长出地面的样品＞花序长出地面但尚未开花的样品＞开花的样品＞花期后的样品；从对卫星搭载样品的分析结果看，毛蕊花糖苷的质量分数具有提高的趋势，而松果菊苷以及半乳糖醇的量变化很小。结论 不同产地、不同加工方法、不同生长期对肉苁蓉活性成分具有影响，为肉苁蓉药材质量控制和采收加工提供参考。

Objective To analyze the crude drug of Cistanche deserticola from different sources and to supply some references for the quality control, collection, and processing of C. deserticola. Methods HPLC-UV method was used to determine the contents of echinacoside and verbascoside, while HPLC-ELSD method was used to determine the content of galactitol. According to the content differences of these compounds, the influences of habitat, processing method, growing period, and space flight on the quality of C. deserticola had been discussed. Results There were great differences among the samples from various sources. The quality of the crude drugs from the genuine producing areas, such as Inner Mongolia and Xinjiang was better than that from Ningxia. The influences of processing methods were different for the three constituents, the drying method for first killing the enzymes was better to echinacoside and verbascoside, the traditional drying method was better to galactitol. The contents of the active constituents in the crude drug underground > those growing above the ground before florescence > those in florescence > those after florescence. The content of verbascoside was higher in C. deserticola carried by space flight than that not carried by space flight, but the contents of echinacoside and galactitol were almost same. Conclusion This method supplies a comprehensive analysis of C. deserticola, which could be used for the quality control, collection and processing of C. deserticola.

科技部十五攻关项目（2001BA701A41，2001BA701A55-34）；中国科学院“西部之光”人才培养计划“联合学者”项目（lhxz200901）；中医药行业科技专项（200707009）