目的 优化中药水提液膜分离前的预处理方式。方法 以黄连解毒汤水提液中4种共性高分子物质和小分子药效物质（小檗碱、栀子苷）组成的综合模拟体系为研究对象，通过不同预处理方式调节溶液环境，分别考察不同溶液环境对膜通量、共性高分子物质去除率、小分子药效物质透过率等指标的影响。结果 调节pH值对膜通量的改善较为明显，共性高分子物质截留率较高；调节pH值和离子强度（加入0.05 mol/L NaCl）时小分子药效物质透过率相对理想。研究发现，膜堵塞阻力是膜污染的主要因素。结论 综合各项指标，黄连解毒汤以调节离子强度和调节pH值为6.5时的预处理效果较为理想；对于中药水提液的膜分离前预处理具有一定的参考意义。

Objective To optimize the pretreatment on the water extract of Chinese materia medica (CMM) before membrane separation. Methods Using the comprehensive simulation system of four common polymers and index components existed in the water extract of CMM (berberine and geniposide) as the research object, the solution environment was adjusted by different pretreatments. The flux of microfiltration, transmittance of the ingredients, and removal rate of common polymers were selected as indicators to study the effects of different solution environments. Results It was found that adjusting pH could change the permeation flux obviously, and the removal rate of common polymers was comparatively higher. The transmittance of index components was higher when the pH value and ionic strength were adjusted (adding 0.05 mol/L NaCl). The membrane blocking resistance was the major factor in membrane fouling. Conclusion Based on the above indicators, the effect of pretreatment is comparatively significant when the ionic strength and pH value are adjusted (pH 6.5 and adding 0.05 mol/L NaCl). It provides a valuable reference for the pretreatment of the water extract of CMM before membrane separation.

国家自然科学基金资助项目（30873449，30973950，81274096，81303230）；中国博士后科学基金资助项目（2013M541704）；江苏省博士后科学基金资助项目（1301133C）；江苏省科技厅产学研联合创新资金——前瞻性研究项目（BY2012036）